Stem cell infusion for severe systemic sclerosis
Part of Skin clinical trials.
This trial tests whether infusions of donor stem cells from fat tissue can help people with severe systemic sclerosis (a serious autoimmune disease that hardens the skin and can affect internal organs). It is for patients who haven't improved with other treatments or cannot undergo a standard stem cell transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have a confirmed diagnosis of systemic sclerosis (scleroderma).
- Your disease is severe – either you've had it for 2 years or less with significant skin tightness and certain blood test results, OR you have at least 15 points on a skin score and major organ involvement (such as lung, kidney, or heart problems).
- You cannot or choose not to have a standard stem cell transplant, and you have not responded to or have side effects from common immune-suppressing medicines like mycophenolate or methotrexate.
- You are willing to use effective birth control during the study (if applicable).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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