Rifaximin plus NAC for IBS with diarrhea
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether a combination of two medications—rifaximin (a gut antibiotic) and NAC (a supplement that helps break down mucus)—can reduce belly pain and diarrhea in people with IBS whose symptoms are not well controlled. It may be an option if other treatments haven't worked well enough.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and not pregnant or breastfeeding.
- You have been diagnosed with IBS where diarrhea is the main symptom (not constipation).
- Your IBS symptoms (like belly pain, loose stools, or urgent need to go) are still present despite any treatments you've tried.
- You do not have asthma, inflammatory bowel disease, celiac disease, or a history of certain stomach surgeries.
- You have not taken antibiotics in the last month, and you are not currently using the study drugs (rifaximin or NAC).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if a special diet (low-FODMAP) combined with a medication (mirtazapine) can improve IBS with diarrhea symptoms. It is for adults who have not tried these treatments before.
This trial tests whether combining brain stimulation (called transcranial magnetic stimulation) with either a medication or a probiotic can help reduce diarrhea and belly pain in people with IBS. If you join, you'll receive one of these combinations to see if it improves your symptoms.
This study tests whether a medicine called rifaximin, taken along with oral rehydration solution, helps children aged 6 to 11 recover faster from acute (short-lasting) diarrhea that is likely caused by a bacterial infection. The study compares rifaximin plus oral rehydration versus oral rehydration alone.
This study tests whether adding a probiotic supplement to the antibiotic rifaximin improves treatment for people with irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO), a condition where too many bacteria grow in the small intestine. If you have IBS and SIBO, this combination might help reduce your symptoms.
This trial tests a medication called rifaximin (an antibiotic that works in the gut) to see if it reduces bloating in people with functional bowel disorders like IBS or chronic constipation. If you have stubborn bloating despite treatment, this could be a new option to help you feel better.
This trial tests whether an oral antibiotic called rifaximin can improve symptoms during a microscopic colitis flare. It aims to see if it is safe and effective for people whose colitis was confirmed by colon biopsy.
Hear when a new IBS-D (Diarrhea-predominant) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.