JMKX000197 for malignant pleural effusion in advanced cancer
Part of Cancer, Lungs & breathing clinical trials.
This trial tests an investigational drug called JMKX000197 given into the chest to control fluid buildup caused by cancer. It is for people with advanced solid tumors that have led to a moderate or large pleural effusion requiring drainage.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have an advanced solid tumor that has spread to cause a moderate or large fluid buildup in your chest (malignant pleural effusion) that needs draining.
- You are well enough to be up and about at least half the day (ECOG score 0–2) and expected to live at least 3 more months.
- Your organs (kidneys, liver, bone marrow) are working well enough based on blood tests.
- You have not received a STING agonist drug into your chest before, and you haven't had major surgery or been in another drug trial in the last 28 days.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new drug called JMKX000197 against a standard chemotherapy drug (cisplatin) to see which is better at reducing fluid buildup around the lungs in people with advanced cancer. The goal is to ease breathing and improve quality of life.
This trial tests a new drug given directly into the chest cavity to treat fluid buildup caused by non-small cell lung cancer. It may help ease breathing problems and control the fluid.
This trial tests whether adding a traditional Chinese medicine called Xuan Yin Ning to an existing drug (bevacizumab) can help control fluid buildup around the lung in people with advanced non-small cell lung cancer. The goal is to reduce symptoms like shortness of breath and improve quality of life.
This study collects fluid that builds up around your lungs (pleural effusion) during a drainage procedure you already need. Researchers test how different drugs affect your cancer cells in the lab to help predict which treatments might work best for you.
This trial tests a procedure called pleural manometry, which measures pressure in the chest during fluid drainage, to see if it helps doctors better assess and treat malignant pleural effusion (fluid buildup around the lung caused by cancer). The goal is to improve symptom relief and treatment decisions.
This study looks at two ways to manage a buildup of fluid around the lung caused by cancer. One method uses a temporary tube to drain the fluid, and the other uses a procedure to seal the space so fluid does not come back. The goal is to see which approach helps people breathe more easily and feel better.
Hear when a new Malignant Pleural Effusions (Mpe) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.