Vaccine, immunotherapy, and radiation for advanced lung cancer
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a combination of a personalized vaccine (made from your tumor's unique markers), a drug that boosts your immune system (PD-1 inhibitor), and targeted radiation for people with advanced lung cancer that has progressed after initial treatment. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced non-small cell lung cancer (NSCLC) that has gotten worse after first treatment.
- You have at least one tumor that can be measured on scans, and you need radiation therapy for some of the cancer spots.
- You are between 18 and 70 years old, and your overall health is good (ECOG score 0-1).
- Your blood counts, liver, kidney, and thyroid function are within normal limits, and you do not have active hepatitis, AIDS, syphilis, or other infections.
- You are not pregnant or breastfeeding, and if you could become pregnant, you agree to use effective birth control during the study and for 6 months after.
- You have not had certain other treatments (like steroids, immunotherapy, or other cancer drugs) in the past few weeks to months, and you have no serious heart, bleeding, or autoimmune conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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