Radiofrequency ablation or vertebroplasty with or without SBRT for painful spine tumors
Treatments studied
Part of Pain clinical trials.
This study tests whether adding a precise type of radiation (called SBRT) to a procedure that stabilizes the spine or shrinks the tumor (radiofrequency ablation or vertebroplasty) can better reduce pain from cancer that has spread to the spine. It might help people whose pain is not controlled by usual treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have cancer that has spread to your spine (between T5 and L5) and is causing pain.
- You have 3 or fewer affected vertebrae, and the tumors are mostly destroying bone (lytic) rather than forming new bone.
- Your pain score is more than 3 out of 10 (0 = no pain, 10 = worst pain).
- You are expected to live more than 3 months.
- You are able to care for yourself (ECOG 0-2) and have adequate organ function (kidney, liver, heart, blood counts).
- You have not had radiation to the target spine area in the last 2 years.
- You do not have certain tumor types that are very sensitive to radiation (like lymphoma or Ewing sarcoma).
- Your tumor does not involve the back part of the spine (spinal appendages), destroy the back wall of the spinal canal, or press on the spinal cord.
- You are not pregnant or planning pregnancy, and you agree to use effective birth control for at least 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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