Bone treatment after stopping denosumab for osteoporosis
Part of Bones, joints & muscles, Hormones & metabolism clinical trials.
This trial tests whether giving zoledronic acid (a bone-strengthening infusion) right after stopping denosumab can help prevent bone loss in women with post-menopausal osteoporosis. It may be a good option if you have finished at least 2 years of denosumab and your doctor says it's safe to stop.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a woman after menopause with osteoporosis.
- You have been taking denosumab for at least 2 years and your doctor has decided it's safe to stop because your bone density is stable and you haven't had new fractures.
- Before starting denosumab, you either had a severe fracture or a bone density score of -2.5 or lower in your spine or hip.
- You have not taken any other bone medications (like bisphosphonates, teriparatide, or romosozumab) in the last year.
- You do not have severe kidney disease or a known intolerance to zoledronic acid.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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