Effects of GLP-1 medications on fertility in PCOS and obesity
Treatments studied
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial tests whether a class of drugs called GLP-1 receptor agonists (often used for diabetes and weight loss) can improve pregnancy outcomes in women with polycystic ovary syndrome (PCOS) who are overweight or obese. If you have PCOS and a BMI between 28 and 35, you may be eligible to participate.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a woman who wants to become pregnant.
- You have been diagnosed with PCOS (using the Rotterdam criteria, which includes signs like irregular periods, high androgen levels, or polycystic ovaries on ultrasound).
- Your body mass index (BMI) is between 28 and 35 (overweight to moderately obese).
- You do not have other medical conditions, hormonal disorders, or liver/kidney problems.
- You have not taken certain medications (like steroids or anti-androgen drugs) in the last 3 months, and you have not had significant weight loss (more than 5%) in the last 3 months.
- You have not had gastrointestinal surgery, have no uterine abnormalities or untreated blocked fallopian tubes, and are not using donor eggs or sperm.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a class of diabetes drugs called GLP-1 receptor agonists can improve fertility in overweight women with polycystic ovary syndrome who want to conceive. These drugs help with weight and blood sugar, which may improve ovulation and pregnancy chances.
This trial tests if liraglutide, a weight-loss medication, can help obese women with PCOS who have a frozen embryo achieve pregnancy. It aims to improve fertility outcomes by aiding weight loss before embryo transfer.
This study tests whether acupuncture or the diabetes medicine metformin can improve insulin resistance in women with PCOS. It may help with hormone-related symptoms and metabolic health, comparing the two approaches against usual care for non-PCOS controls.
This study looks at how weight changes affect hormone levels and insulin resistance in women with PCOS. It may help understand if weight cycling is harmful or helpful.
This study tests whether acupuncture can help women with PCOS (a hormone condition) who are overweight or obese lose weight and improve their chances of getting pregnant. The trial compares acupuncture with a standard treatment to see if it makes a difference.
This study tests whether the weight-loss drug orlistat can improve blood sugar, hormones, and other metabolic measures in women with polycystic ovary syndrome (PCOS). If you have PCOS and are overweight, this treatment might help with symptoms like irregular periods and excess hair growth.
Hear when a new Polycystic Ovary Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.