Treatment
Metformin clinical trials
We’re tracking 153 recruiting studies that include Metformin, each written for real people, not researchers, below.
Recruiting studies
- NCT05036226RecruitingPhase 1/Phase 2
COAST therapy for advanced prostate or other solid tumors
This early-phase trial tests the COAST therapy approach in people with advanced solid tumor cancers or advanced prostate cancer that has continued to grow despite standard treatments. The study aims to see how well the treatment works and whether it is safe enough to continue studying.
Charleston, South CarolinaAges 18 years+ - NCT06888050RecruitingPhase 4
Study of new diabetes pill versus metformin for new type 2 diabetes
This trial tests a new combination pill (henagliflozin and metformin) compared to metformin alone in people recently diagnosed with type 2 diabetes. The goal is to see which treatment works better and is safer.
Hangzhou, ZhejiangAges 18–75 - NCT06064669Recruiting
Metformin for healthy live birth in women with prediabetes
This study tests if metformin, a drug that helps control blood sugar, can improve the chance of a healthy live birth in women with prediabetes who are doing in vitro fertilization (IVF). It aims to see if treating prediabetes before and during early pregnancy leads to better outcomes.
Jinan, ShandongAges 20–40 - NCT06570980Recruiting
Comparing two diabetes drugs taken with metformin
This study looks at two common diabetes pills (sulfonylureas and DPP4 inhibitors) when used together with metformin. It aims to find out which combination is more cost-effective for treating type 2 diabetes.
DhakaAges 18 years+ - NCT06863532Recruiting
Comparing two add-on treatments for type 2 diabetes
This trial compares adding a new pill (cofrogliptin) to increasing your current metformin dose, for people whose blood sugar is still too high despite taking an SGLT2 inhibitor and a low dose of metformin. The goal is to see which option works better and is safer.
Hangzhou, ZhejiangAges 18–74 - NCT06459310RecruitingPhase 2
Testing metformin to slow aging in healthy men
This study tests whether metformin can help slow aging in healthy men. You might be eligible if you are a man in one of two age groups and do not have major health problems.
BeijingAges 18–65 - NCT07019012RecruitingPhase 4
Testing a new every-2-week pill for type 2 diabetes
This study tests a new once-every-2-weeks pill (cofrogliptin) added to your current diabetes medications (metformin and dapagliflozin) compared to a daily pill (linagliptin). It may help improve blood sugar control with fewer daily pills.
Wuhan, HubeiAges 18 years+ - NCT07307677Recruiting
Melatonin and metformin for PCOS with insulin resistance
This study tests if adding melatonin to metformin can improve insulin resistance and other health markers in women with PCOS who have insulin resistance. It compares the combination to metformin alone.
Dhaka, ShahbagAges 18–35 - NCT04581447RecruitingPhase 3
Metformin to help prevent diabetes returning after weight surgery
This Phase 3 study tests whether adding metformin after gastric bypass or sleeve surgery can help you stay free of diabetes for longer. It compares metformin plus standard care versus standard care alone.
AmiensAges 18–70 - NCT05469659RecruitingPhase 2
Test drug to slow kidney damage in type 2 diabetes
This Phase 2 study compares tofogliflozin to metformin to see how well they reduce urine albumin levels (a marker of kidney stress) in people with diabetic kidney disease. You might benefit if your type 2 diabetes is affecting your kidneys despite standard blood-pressure medicines.
Matsumoto, NaganoAges 20 years+ - NCT05929495RecruitingPhase 2
Metformin added to standard treatment for newly diagnosed glioblastoma
This Phase 2 study tests whether adding metformin to the usual treatment for newly diagnosed glioblastoma (GBM) can improve outcomes. It involves taking metformin after surgery along with standard care (the Stupp protocol).
MilanAges 18 years+ - NCT06273072RecruitingPhase 2
Metformin for asthma in overweight adults
This trial tests whether the diabetes drug metformin can help people with asthma who are also overweight or obese. The goal is to see if it improves asthma control and reduces the need for rescue medications.
Baltimore, MarylandAges 18 years+ - NCT06325956Recruiting
PCOS immune function predicts metformin success
This study tests whether your immune system's health can predict how well metformin works for PCOS. It aims to help doctors choose the right treatment for each person.
ShanghaiAges 18–45 - NCT06424860RecruitingPhase 1
Fish Oil, Metformin and Heart Health in PCOS
This trial tests whether fish oil and metformin can improve heart health in people with PCOS who are overweight or have high blood sugar or fats. It combines two common approaches to see if they work better together.
Edmonton, AlbertaAges 25–45 - NCT06932874RecruitingPhase 4
Metformin for diabetes with heart disease
This trial tests a long-acting metformin pill in people with both type 2 diabetes and coronary heart disease. It aims to see if metformin can safely help control blood sugar in this specific group.
Beijing, Beijing MunicipalityAges 30–75 - NCT02915198RecruitingPhase 4
Metformin for prediabetes to reduce heart and blood-vessel events
This trial tests whether taking metformin in people with prediabetes can lower the chance of future heart attack, stroke, or other blood-vessel problems. You may be a good fit if you have prediabetes plus existing cardiovascular disease or significant blood-vessel disease.
Phoenix, ArizonaAges 18 years+ - NCT07452913Enrolling by invitationPhase 4
Comparing Diabetes Drug Combinations in Newly Treated Adults
This trial compares two different combinations of diabetes pills (metformin plus empagliflozin with either sitagliptin or linagliptin) in people with type 2 diabetes who have not been treated before. It aims to see which combination works better and is safer for controlling blood sugar.
Karachi, SindhAges 30–55 - NCT07771010RecruitingPhase 4
Comparing empagliflozin and metformin for muscle health in type 2 diabetes
This study tests two diabetes medications, empagliflozin and metformin, to see how they affect muscle energy use and blood flow in men with recently diagnosed type 2 diabetes. Participants will be followed at a diabetes clinic.
LjubljanaAges 18–75 - NCT07226453RecruitingPhase 2
Metformin for recurrent PFA ependymoma
This trial tests if metformin can help treat a certain type of brain tumor called PFA ependymoma that has come back after surgery and radiation. It's for people ages 1 to 39 who are healthy enough for surgery or have tumors that can be measured on scans.
Birmingham, AlabamaAges 1–39 - NCT07446400RecruitingPhase 1
Drug interaction study for repinatrabit
This trial tests how repinatrabit interacts with common medications like birth control, metformin, and others. It helps doctors understand safe dosing and potential side effects.
Melbourne, VictoriaAges 18–55 - NCT07188740RecruitingPhase 1
Metformin to target leukemia-related mutation during remission
This trial tests if metformin can reduce a specific mutation (DNMT3A R882) in people with acute leukemia who are in remission. The goal is to see if it helps prevent relapse.
Tianjin, Tianjin MunicipalityAges 14 years+ - NCT07654179Recruiting
Metformin for depression with obesity: a genetic study
This trial tests if adding metformin to antidepressants helps people who have both depression and obesity. It also looks at genetic factors that might affect treatment response.
Rawalpindi, Punjab ProvinceAges Any age - NCT05205317Recruiting
VR alone or VR plus metformin for C-section scar healing
This study compares two treatments to help improve a C-section scar defect (an issue seen on the uterus scar). Some participants may receive virtual reality (VR) therapy plus metformin, while others receive VR alone, and the researchers will look at symptoms and scar healing.
Shanghai, Shanghai MunicipalityAges 18–40 - NCT07098299RecruitingPhase 1
Metformin with chemotherapy or immunotherapy for advanced solid tumors
This trial tests if adding metformin, a common diabetes drug, to standard chemotherapy or immunotherapy can help treat advanced solid tumors. It may be an option for people who are already eligible for chemo or immunotherapy.
Bay City, MichiganAges 18 years+
What Metformin is being studied for
Conditions with recruiting Metformin studies.
Common questions
- Are there clinical trials studying Metformin?
- Yes. Clin2 currently lists 153 recruiting studies that include Metformin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Metformin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Metformin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Metformin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.