Treatment
Metformin clinical trials
We’re tracking 146 recruiting studies that include Metformin, each written for real people, not researchers, below.
Recruiting studies
- NCT05036226RecruitingPhase 1/Phase 2
COAST therapy for advanced prostate or other solid tumors
This early-phase trial tests the COAST therapy approach in people with advanced solid tumor cancers or advanced prostate cancer that has continued to grow despite standard treatments. The study aims to see how well the treatment works and whether it is safe enough to continue studying.
Charleston, South CarolinaAges 18 years+ - NCT06888050RecruitingPhase 4
Study of new diabetes pill versus metformin for new type 2 diabetes
This trial tests a new combination pill (henagliflozin and metformin) compared to metformin alone in people recently diagnosed with type 2 diabetes. The goal is to see which treatment works better and is safer.
Hangzhou, ZhejiangAges 18–75 - NCT06863532Recruiting
Comparing two add-on treatments for type 2 diabetes
This trial compares adding a new pill (cofrogliptin) to increasing your current metformin dose, for people whose blood sugar is still too high despite taking an SGLT2 inhibitor and a low dose of metformin. The goal is to see which option works better and is safer.
Hangzhou, ZhejiangAges 18–74 - NCT06064669Recruiting
Metformin for healthy live birth in women with prediabetes
This study tests if metformin, a drug that helps control blood sugar, can improve the chance of a healthy live birth in women with prediabetes who are doing in vitro fertilization (IVF). It aims to see if treating prediabetes before and during early pregnancy leads to better outcomes.
Jinan, ShandongAges 20–40 - NCT07307677Recruiting
Melatonin and metformin for PCOS with insulin resistance
This study tests if adding melatonin to metformin can improve insulin resistance and other health markers in women with PCOS who have insulin resistance. It compares the combination to metformin alone.
Dhaka, ShahbagAges 18–35 - NCT07019012RecruitingPhase 4
Testing a new every-2-week pill for type 2 diabetes
This study tests a new once-every-2-weeks pill (cofrogliptin) added to your current diabetes medications (metformin and dapagliflozin) compared to a daily pill (linagliptin). It may help improve blood sugar control with fewer daily pills.
Wuhan, HubeiAges 18 years+ - NCT06932874RecruitingPhase 4
Metformin for diabetes with heart disease
This trial tests a long-acting metformin pill in people with both type 2 diabetes and coronary heart disease. It aims to see if metformin can safely help control blood sugar in this specific group.
Beijing, Beijing MunicipalityAges 30–75 - NCT06459310RecruitingPhase 2
Testing metformin to slow aging in healthy men
This study tests whether metformin can help slow aging in healthy men. You might be eligible if you are a man in one of two age groups and do not have major health problems.
BeijingAges 18–65 - NCT06424860RecruitingPhase 1
Fish Oil, Metformin and Heart Health in PCOS
This trial tests whether fish oil and metformin can improve heart health in people with PCOS who are overweight or have high blood sugar or fats. It combines two common approaches to see if they work better together.
Edmonton, AlbertaAges 25–45 - NCT06273072RecruitingPhase 2
Metformin for asthma in overweight adults
This trial tests whether the diabetes drug metformin can help people with asthma who are also overweight or obese. The goal is to see if it improves asthma control and reduces the need for rescue medications.
Baltimore, MarylandAges 18 years+ - NCT05929495RecruitingPhase 2
Metformin added to standard treatment for newly diagnosed glioblastoma
This Phase 2 study tests whether adding metformin to the usual treatment for newly diagnosed glioblastoma (GBM) can improve outcomes. It involves taking metformin after surgery along with standard care (the Stupp protocol).
MilanAges 18 years+ - NCT05469659RecruitingPhase 2
Test drug to slow kidney damage in type 2 diabetes
This Phase 2 study compares tofogliflozin to metformin to see how well they reduce urine albumin levels (a marker of kidney stress) in people with diabetic kidney disease. You might benefit if your type 2 diabetes is affecting your kidneys despite standard blood-pressure medicines.
Matsumoto, NaganoAges 20 years+ - NCT04581447RecruitingPhase 3
Metformin to help prevent diabetes returning after weight surgery
This Phase 3 study tests whether adding metformin after gastric bypass or sleeve surgery can help you stay free of diabetes for longer. It compares metformin plus standard care versus standard care alone.
AmiensAges 18–70 - NCT02915198RecruitingPhase 4
Metformin for prediabetes to reduce heart and blood-vessel events
This trial tests whether taking metformin in people with prediabetes can lower the chance of future heart attack, stroke, or other blood-vessel problems. You may be a good fit if you have prediabetes plus existing cardiovascular disease or significant blood-vessel disease.
Phoenix, ArizonaAges 18 years+ - NCT07452913Enrolling by invitationPhase 4
Comparing Diabetes Drug Combinations in Newly Treated Adults
This trial compares two different combinations of diabetes pills (metformin plus empagliflozin with either sitagliptin or linagliptin) in people with type 2 diabetes who have not been treated before. It aims to see which combination works better and is safer for controlling blood sugar.
Karachi, SindhAges 30–55 - NCT04530383RecruitingPhase 2
Metformin add-on for adult cystic-fibrosis related diabetes on CF meds
This trial tests whether adding metformin can improve blood-sugar control and related lung cell function in adults who have cystic-fibrosis–related diabetes (CFRD) and are already taking CFTR modulator therapy. It may help if your diabetes is still not well controlled despite those CF medicines.
Kansas City, KansasAges 18 years+ - NCT06862739RecruitingPhase 4
Testing a 3-drug combination for better blood sugar control
This study tests a combination of three diabetes medicines (empagliflozin, linagliptin, and metformin) to see if it helps control blood sugar in people with type 2 diabetes. It may be an option if your current treatment isn't working well enough.
Faisalabad, Punjab ProvinceAges 18–80 - NCT07387900RecruitingPhase 2
Metformin for preventing cancer in oral leukoplakia
This study tests if metformin — a medication commonly used for diabetes — can prevent oral leukoplakia from turning into cancer when applied as a mouth rinse and taken as a pill. It is for people with non-severe white patches in the mouth.
CairoAges 21 years+ - NCT07372625RecruitingPhase 1
How rezatapopt affects common drugs in advanced solid tumors with TP53 Y220C mutation
This trial tests how rezatapopt changes the way your body processes four common medicines (metformin, rosuvastatin, repaglinide, and midazolam) in people with advanced solid tumors that have a specific TP53 Y220C gene change. It helps doctors understand the right dose for future patients.
Denver, ColoradoAges 18 years+ - NCT05132439RecruitingPhase 3
Metformin to improve walking in leg artery blockage
This Phase 3 study tests whether metformin can help people with intermittent claudication (leg pain when walking) walk farther. It compares how well metformin works on walking ability alongside standard (already recommended) heart and blood-vessel medicines.
Pittsburgh, PennsylvaniaAges 35–89 - NCT06829238RecruitingPhase 4
Metformin to boost immune function in people with a history of drug use
This study tests whether metformin, a common diabetes drug, can help restore immune system balance in people who have used injection drugs in the past. It includes both people living with HIV and those who are HIV-negative.
Birmingham, AlabamaAges 18–64 - NCT07331389RecruitingPhase 1
How HDM1002 interacts with common drugs and diabetes medications
This study tests how a new drug called HDM1002 interacts with common diabetes medications (metformin, empagliflozin) and other drugs like warfarin and valsartan. If you are a generally healthy adult (age 18-45) with a higher BMI, this trial helps ensure the new drug is safe when taken with other medicines.
HefeiAges 18–45 - NCT05205317Recruiting
VR alone or VR plus metformin for C-section scar healing
This study compares two treatments to help improve a C-section scar defect (an issue seen on the uterus scar). Some participants may receive virtual reality (VR) therapy plus metformin, while others receive VR alone, and the researchers will look at symptoms and scar healing.
Shanghai, Shanghai MunicipalityAges 18–40 - NCT07297290RecruitingPhase 3
Testing Metformin for Weight Loss in Obesity
This trial tests whether metformin, a common diabetes medicine, can help people with obesity lose weight. It is for people who do not have diabetes and have not used weight loss treatments in the past year.
Enugu, Enugu StateAges 20–59
What Metformin is being studied for
Conditions with recruiting Metformin studies.
Common questions
- Are there clinical trials studying Metformin?
- Yes. Clin2 currently lists 146 recruiting studies that include Metformin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Metformin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Metformin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Metformin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.