Clin2
NCT06778863Possibly a fitRecruiting

A study of CLSP-1025 for adults with certain solid tumors

Advanced Solid TumorUnresectable Solid TumorMetastatic Solid TumorColorectal AdenocarcinomaPancreatic AdenocarcinomaLung CancerOvarian CancerBreast Cancer

Part of Cancer, Hormones & metabolism, Kidney & urinary, Lungs & breathing, Skin, Women’s health & pregnancy clinical trials.

This trial tests a new drug called CLSP-1025 for people with advanced solid tumors that have a specific change in the p53 gene (R175H). The drug targets this change to help fight the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
90 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • Your tumor has a specific p53 R175H mutation confirmed by a lab test.
  • You have a certain immune system marker called HLA-A*02:01.
  • Your cancer has spread or cannot be removed by surgery, and standard treatments have stopped working or are not available.
  • Your performance status is 0 or 1, meaning you are fully active or able to do light work.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05877599Recruiting· Phase 1
Study of a new treatment for advanced cancers with a specific gene change

This trial tests a new type of therapy (NT-175) for people with certain advanced cancers that have a specific genetic change. It might help if your tumor has the TP53 R175H mutation and you have the HLA-A*02:01 immune marker.

Gilbert, Arizona
NCT07650357Not yet recruiting· Phase 1
Study of an investigational therapy for advanced solid tumors with a KRAS G12V mutation

This study tests a new treatment for people with advanced solid tumors that have a specific genetic change called KRAS G12V. The treatment is designed to help the immune system attack cancer cells with this mutation, and the study aims to see if it is safe and effective.

Durham, North Carolina
NCT07304128Recruiting· Phase 1
PLB-002 for advanced solid tumors study

This trial tests a new drug called PLB-002 for people with advanced solid tumors that have stopped responding to standard treatments. It aims to see if the drug is safe and effective, especially for cancers that show a specific marker called CLDN6.

Shanghai, Shanghai Municipality
NCT07752875Not yet recruiting· Phase 1/Phase 2
Study of LG00313112 for advanced tumors with TP53 Y220C mutation

This trial tests a new drug called LG00313112 in people with advanced solid tumors that have a specific genetic change called TP53 Y220C. The drug is designed to target tumors with this mutation, and the study aims to see if it can help shrink or control the cancer.

NCT07256782Recruiting· Phase 1/Phase 2
A study of QLC5508 combinations for advanced solid tumors

This trial tests a new drug called QLC5508, given in combination with other treatments, for people with advanced solid tumors that have stopped responding to standard therapy or who haven't had treatment yet. The goal is to see if the combination can shrink tumors or slow their growth.

Shanghai
NCT06446388Not yet recruiting· Phase 2
Study of new drugs with chemotherapy for advanced solid tumors

This trial tests a combination of two new drugs (QLS31905 and/or QL1706) with chemotherapy for people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to see if this combination can shrink tumors and help people live longer.

Beijing, Beijing Municipality

Hear when a new Advanced Solid Tumor trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.