MDMA for people with vasopressin deficiency
Treatments studied
Part of Hormones & metabolism, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study tests whether a low dose of MDMA, compared to a placebo, changes oxytocin levels in people with a condition called arginine vasopressin deficiency (also known as central diabetes insipidus). The goal is to understand the role of oxytocin in this condition and explore potential treatment insights.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (18 years or older).
- You have a confirmed diagnosis of arginine vasopressin deficiency (central diabetes insipidus) or only anterior pituitary deficiency.
- You do not have any major heart or blood pressure problems like uncontrolled high blood pressure, heart failure, or a recent stroke.
- You are not currently taking certain antidepressants (SSRIs or MAOIs) or have a history of major psychiatric disorders like severe depression or schizophrenia.
- You do not use illegal drugs (cannabis more than 10 times ever or in the last 2 months is allowed).
- You do not drink more than 15 alcoholic drinks per week or smoke more than 10 cigarettes daily.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a nasal spray containing oxytocin can improve sexual well-being in people with a condition called arginine vasopressin deficiency (a problem with a hormone that controls water balance). Healthy volunteers who have mild sexual issues will also take part for comparison. Participants receive either the oxytocin spray or a placebo and fill out questionnaires about their sex life.
This study tests whether a drug called MDMA changes oxytocin levels (a hormone related to social bonding) differently in autistic adults compared to non-autistic adults. Researchers want to understand if MDMA might help with social challenges some autistic people experience.
This study tests if a nasal spray with oxytocin (a natural hormone) can improve emotion recognition and reduce stress-related hormone levels in people with central diabetes insipidus compared to healthy volunteers.
This trial looks at how the body's oxytocin level changes after taking estrogen pills. It includes healthy people and those with a condition called AVP-deficiency (a lack of a hormone that controls water balance). The study aims to understand how estrogen affects oxytocin.
This trial tests whether listening to music modified by a special technology changes oxytocin levels in the blood. It may help us understand how music affects social bonding and stress.
This early-phase study tests whether a spray of oxytocin in the nose can be given safely and may affect symptoms in people with arginine-vasopressin deficiency. You might qualify if your hormone levels are stable and you can safely take the nasal study medicine during the study period.
Hear when a new Central Diabetes Insipidus trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.