Chemo and radiation before surgery for advanced rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests giving a strong chemotherapy combination (FOLFIRINOX) followed by radiation before surgery for locally advanced rectal cancer. If you have stage 3 or high-risk stage 2 rectal cancer that has not spread, this approach may shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with rectal adenocarcinoma (a type of rectal cancer).
- Your cancer is locally advanced (stage cT3 with high risk, cT4, or has spread to nearby lymph nodes) and has not spread to distant parts of the body.
- Your cancer can be removed with surgery, or the doctors believe it could become removable after radiation and chemo.
- You have good overall health (able to care for yourself, up and about) and no major heart, nerve, or other medical problems.
- You have not had radiation to the pelvic area or certain chemotherapies before.
- If you could become pregnant, you must use reliable birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of chemotherapy and radiation therapy before surgery for people with mid or low rectal cancer that hasn't spread. The goal is to see if this approach works better than current treatments.
This Phase 3 trial compares different chemotherapy and radiation combinations given before surgery for locally advanced rectal cancer, to see which one works better. It may help people get a tumor removed completely (R0 resection) and improve outcomes while comparing treatment safety and effectiveness.
This trial tests whether combining chemotherapy (mFOLFOX6) and a short course of radiation before surgery improves outcomes for people with resectable rectal cancer. The goal is to shrink and control the cancer early and then remove it with curative surgery.
This study tests a sequence of chemotherapy and radiation before and after surgery for rectal cancer. It compares giving more chemo between the end of radiation and surgery (consolidation) versus giving some chemo before radiation starts (induction). The goal is to see which order works better.
This Phase 3 trial compares two treatment plans given before rectal surgery. It tests whether stronger chemotherapy alone works better than chemotherapy pills plus long-term radiation to improve outcomes for locally advanced rectal cancer.
This trial tests whether giving chemotherapy before surgery can improve outcomes for people with colon cancer that has grown into nearby tissue or lymph nodes but hasn't spread to other organs. It is for patients whose tumors are mismatch repair proficient (pMMR) or microsatellite stable (MSS).
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