Comparing two antibiotics for liver patients with hospital infections
Treatments studied
Part of Digestive system clinical trials.
This study compares two strong antibiotics—ceftazidime-avibactam and a high dose of meropenem given over a longer infusion—in patients with advanced liver disease who develop a hospital-acquired infection. The goal is to see which works better and is safer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- You must have acute-on-chronic liver failure (ACLF).
- You must have a new infection that started at least 2 days after being admitted to the hospital.
- You cannot be in severe septic shock or have multiple organ failure that needs a change in antibiotics.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two ways of giving preventive antibiotics to liver transplant patients who carry resistant bacteria. The goal is to see if targeted antibiotics work better than standard ones at preventing infections without causing more side effects.
This trial tests whether giving the antibiotic ceftazidime-avibactam continuously or intermittently works better for ICU patients with severe infections caused by drug-resistant bacteria. The goal is to see which method improves outcomes.
This study tests a precise dosing approach for the antibiotic ceftazidime-avibactam to treat serious infections in ICU patients. It aims to help people with hard-to-treat bacteria that are resistant to many other antibiotics.
This trial studies whether cefiderocol plus ampicillin-sulbactam works better than colistin (sometimes with meropenem) for serious infections caused by carbapenem-resistant Acinetobacter baumannii (a hard-to-treat germ). It may help by finding a more effective antibiotic plan for people with these severe hospital-acquired infections.
This study watches how safely two common antibiotics (vancomycin and a combination called piperacillin/tazobactam) work together in hospitalized patients with serious infections. Researchers want to make sure the combination doesn't harm kidney function.
This study tests whether combining two antibiotics (ceftazidime and fosfomycin) works better than ceftazidime alone for hospitalized adults with serious bacterial infections. If you have a severe infection thought to be caused by Gram-negative bacteria, this trial may offer a new treatment option.
Hear when a new Acute-On-Chronic Liver Failure trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.