Testing a single dose of CYB003 for depression and anxiety
Treatments studied
Part of Mental health clinical trials.
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 21 and 65 years old.
- You have a diagnosis of major depressive disorder (MDD) and at least moderate depression and anxiety (scores of 21+ on the MADRS scale and 10+ on the GAD-7).
- You are currently taking a stable dose of an SSRI or SNRI antidepressant, but it hasn't worked well enough for your current depression episode.
- You are not pregnant, breastfeeding, or planning to become pregnant, and you agree to use effective birth control during the study and for 3 months after.
- You do not have a history of bipolar disorder, schizophrenia, certain other mental health conditions, or serious suicide risk.
- You have not used certain psychedelics (like psilocybin, LSD) more than 10 times in the last 10 years, or at all in the past 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
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