Metformin to boost immune function in people with a history of drug use
Treatments studied
Part of Immune system & allergy, Infections clinical trials.
This study tests whether metformin, a common diabetes drug, can help restore immune system balance in people who have used injection drugs in the past. It includes both people living with HIV and those who are HIV-negative.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 64 years old.
- You have used injection opioids, amphetamines, or cocaine in the last 10 years and within the past 30 days.
- Your blood tests show higher than normal inflammation (CRP) and certain glucose and immune markers.
- You are willing to receive the Jynneos (MPOX) and Capvaxvie vaccines.
- You have not taken metformin or any other diabetes medicine recently.
- You do not have diabetes, severe liver or kidney disease, or certain other medical conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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