Metformin to boost immune function in people with a history of drug use
Treatments studied
Part of Immune system & allergy, Infections clinical trials.
This study tests whether metformin, a common diabetes drug, can help restore immune system balance in people who have used injection drugs in the past. It includes both people living with HIV and those who are HIV-negative.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 64 years old.
- You have used injection opioids, amphetamines, or cocaine in the last 10 years and within the past 30 days.
- Your blood tests show higher than normal inflammation (CRP) and certain glucose and immune markers.
- You are willing to receive the Jynneos (MPOX) and Capvaxvie vaccines.
- You have not taken metformin or any other diabetes medicine recently.
- You do not have diabetes, severe liver or kidney disease, or certain other medical conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new drug called JL18008 (a man-made form of Interleukin-7) to see if it can help increase CD4 immune cells in people with HIV who are on effective antiretroviral therapy but have persistently low CD4 counts (between 100 and 350). It aims to improve immune function.
This study tests whether giving a small protein called IL-15 can help your immune system keep HIV under control after pausing your daily HIV medications. You will stop your meds for a short time under careful monitoring, and the hope is that your body might learn to fight HIV without daily pills.
This trial tests if a once-weekly diabetes medication (semaglutide) can help people with HIV reduce heavy drinking and improve heart health. It's for people who drink alcohol and have a higher body weight.
This trial tests if metformin, a diabetes pill, can help older adults with COPD recover better from flare-ups when taken during pulmonary rehabilitation. It focuses on people who have had frequent or severe COPD exacerbations in the last year.
This study tests an experimental drug called JL18008 in people with HIV who have been on stable HIV medications for years but whose immune systems (CD4 cells) haven't recovered as expected. The drug may help boost immune function in these patients.
This study tests a new medication to see if it can improve how your body responds to insulin and boost your cells' energy (mitochondrial function). It is for adults with type 1 diabetes who are already on insulin and have good overall health.
Hear when a new Systemic Inflammation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.