Clin2
NCT06838676Possibly a fitRecruiting

ACT001 for Newly or Previously Treated Brain Stem Glioma

Diffuse Intrinsic Pontine Gliomas (DIPG)Progressive DIPGRefractory DIPGRecurrent DIPGH3K27-altered High Grade Glioma

Part of Brain & nervous system, Cancer clinical trials.

This trial tests the drug ACT001 in people with a type of brain tumor called DIPG or other related high-grade gliomas. It aims to see if the drug can help control the tumor and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
60 people
Ages
1 year to 39 years
Study type
Interventional

Who can take part

  • You are between 1 and 39 years old.
  • You have been diagnosed with DIPG or a related high-grade glioma.
  • If newly diagnosed, you have completed radiation therapy within the last 28-35 days.
  • If the tumor has come back or not responded to treatment, you must have had radiation as part of your prior treatment.
  • You are well enough to carry out daily activities (performance score at least 50%).
  • Your organ function (bone marrow, kidneys, liver, heart) is within normal limits.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07869524Not yet recruiting· Phase 3
Comparing two radiation therapies for a rare brain tumor

This trial compares two types of radiation therapy for children with diffuse intrinsic pontine glioma (DIPG), a rare brain tumor. It aims to see which treatment may be more effective while helping you understand your options.

Jinan, Shandong
NCT05839379Recruiting
Targeted therapy study for children and young adults with brain tumors

This trial studies a targeted medicine approach for high-grade glioma (a fast-growing brain tumor) and some diffuse midline tumors, including DIPG. It may help by matching treatment to tumor biology using tumor testing done before or around starting standard therapy.

Aurora, Colorado
NCT06894225Recruiting· Phase 2
Targeted drug for recurrent brain cancer with STAT3 marker

This trial tests a new drug called ACT001 for people with recurrent glioblastoma (a type of brain cancer) whose tumors have a specific marker (STAT3-high). The drug targets that marker to try to stop the tumor from growing.

Singapore
NCT06305910Recruiting· Phase 1
Vaccine immunotherapy for recurrent brain tumors or newly diagnosed DIPG

This trial tests a combination of a vaccine made from tumor cells and a drug that may boost the immune system's ability to fight brain tumors. It is for children and young adults with a recurrent high-grade glioma or a newly diagnosed diffuse midline glioma with a specific genetic marker (H3K27M).

Minneapolis, Minnesota
NCT04943848Recruiting· Phase 1
Vaccine plus immune treatment for newly diagnosed brain stem tumors

This early-phase trial tests a customized vaccine (made from your tumor’s cell parts) along with an immune “checkpoint blocker” medicine. It’s for newly diagnosed DIPG/DMG to see if this combination is safe and can help control the cancer.

Orange, California
NCT04870944Recruiting· Phase 1/Phase 2
CBL0137 for children with advanced solid or brain tumors

This early-phase study tests CBL0137 in children and teens whose cancer has come back or is not responding to treatment. It is also for some specific hard-to-treat brain tumors, to see if the drug is safe and can work against the cancer.

Birmingham, Alabama

Hear when a new Diffuse Intrinsic Pontine Gliomas (DIPG) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.