Methadone for pain during and after spine surgery
Part of Pain clinical trials.
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You are having planned spine surgery that involves fusing bones in your neck, back, or lower back.
- You agree to use birth control if you could become pregnant.
- You are not allergic to methadone or any other opioid pain medicine.
- You do not have serious breathing, heart, liver, or kidney problems.
- You have not used an MAO inhibitor medicine in the last 14 days.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether giving methadone during and after major spine surgery can help reduce the need for other opioid pain medicines later. It is for adults having multilevel fusion in the lower or mid-back.
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This study tests whether giving a single dose of methadone during surgery can improve pain relief after the operation, possibly reducing the need for other painkillers and helping you recover more comfortably. It is for people having certain planned surgeries that require an overnight stay in the hospital.
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This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
This study tests a combination of three medications (methadone, dexmedetomidine, and ketamine) to control pain after major spine surgery. If you are having complex spine surgery, this trial may offer better pain relief without needing as much opioid medication.
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