Tailoring breathing support and muscle relaxants during prone positioning for severe lung injury
Part of Lungs & breathing clinical trials.
This trial tests two ways to adjust ventilator settings for patients with severe lung injury whose oxygen levels are very low. It aims to find out the best level of breathing support and whether giving muscle relaxants during prone positioning helps improve oxygen levels.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be on a breathing machine through a tube in your windpipe within the last 4 days of being in the ICU, and within 3 days of that tube being placed.
- Your oxygen levels must be very low (PaO2/FiO2 of 150 or less) even with the breathing machine set to certain levels.
- You or your family member must agree in writing to the trial, or you can be enrolled in an emergency if no one is available.
- You must have health insurance coverage.
- You cannot have certain other serious conditions like severe chronic lung disease, recent head injury with high pressure in the brain, or be on a heart-lung machine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new way to adjust the amount of air given by the ventilator to people with a severe lung injury called ARDS. The goal is to see if a specific breathing strategy can help protect the lungs and improve recovery.
This trial tests whether combining two treatments—medications that relax muscles (neuromuscular blocking agents) and lying on your stomach (prone positioning)—can reduce lung damage in people with severe ARDS on a breathing machine.
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This study compares a more careful ventilation approach for people with severe lung breathing failure (ARDS). It aims to improve outcomes by using a specific strategy for how the ventilator controls breathing.
This trial studies whether turning patients onto their stomach (a positioning technique called prone positioning) changes a breathing-monitoring measure in people with severe acute respiratory distress syndrome (ARDS). If you qualify, the goal is to see if this positioning can improve how well your lungs exchange oxygen while you are on a breathing machine.
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