Bisphosphonate before parathyroid surgery for bone health
Treatments studied
Part of Hormones & metabolism clinical trials.
This study tests whether giving a bisphosphonate (a bone-strengthening drug) before parathyroid surgery helps protect bone health in people with primary hyperparathyroidism. It's for those who already have thin bones and are planning surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a postmenopausal woman or a man over 50 years old.
- You have been diagnosed with primary hyperparathyroidism (high calcium) and are planning to have surgery to remove the parathyroid gland.
- Your bone density is lower than normal (T-score of -1 or less) at the hip, thigh bone, or lower spine.
- Your vitamin D level is at least 50 nmol/l before starting the study.
- You do not have kidney problems (eGFR below 35), allergy to bisphosphonates, recent major dental surgery, or other conditions/medications that affect bone health.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study tests how well a special PET scan using a substance called choline finds overactive parathyroid glands before you have surgery. It may help surgeons remove the right gland and avoid removing healthy ones.
This study looks at whether a special scan (choline PET/CT) done before surgery can replace the need for a quick hormone test during parathyroid surgery. It may help make surgery faster and less invasive.
This study tests two advanced imaging techniques (PET/MR and PET/CT) to find overactive parathyroid glands or tumors that need surgery. Participants get a special scan before surgery to help surgeons locate the problem more accurately.
This trial looks at whether removing overactive parathyroid glands (parathyroidectomy) can help people who still have high calcium or low phosphate levels more than 6 months after a kidney transplant. If you have stable kidney function and meet certain blood test results, you may be able to join.
This trial tests teriparatide (a hormone-like bone medicine) to improve bone health in people with advanced chronic kidney disease who are at risk for weak, low-turnover bone. It may help by changing how quickly your bones break down and rebuild.
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