Thiotepa added to standard chemo before a stem cell transplant for older adults with high-risk AML
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests whether adding a drug called thiotepa to the usual chemotherapy (busulfan and fludarabine) before a half-matched stem cell transplant can safely and effectively treat older adults (55–70) with high-risk AML.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 55 and 70 years old.
- You have a high-risk form of acute myeloid leukemia (AML), which may include leukemia that came back after treatment or is hard to treat.
- You are planning to receive a stem cell transplant from a half-matched family donor (haploidentical transplant).
- Your major organs (heart, liver, kidneys, lungs) work well enough for the transplant.
- You are still able to do most daily activities (like walking and getting dressed) with little or no help.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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