Clinical trials
Cluster Headache clinical trials
Below are recruiting cluster headache clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03781128RecruitingPhase 2
LSD for cluster headaches in a clinical study
This Phase 2 study tests whether a supervised dose of LSD (or a placebo) can reduce cluster headache attacks. It’s for people whose cluster headaches respond to oxygen, and who can safely pause certain medications and substances around the dosing day.
BaselAges 25–75 - NCT03944876RecruitingPhase 3
Botulinum toxin to block a facial nerve for chronic cluster headaches
This trial tests whether injections of botulinum toxin type A can reduce frequent, severe cluster headache attacks by targeting a facial nerve area. It’s for people whose cluster headaches have not responded well—or have caused side effects—to standard preventive treatments.
HamburgAges 18–85 - NCT06503328Recruiting
Cluster headache microRNA study
This study aims to understand how certain tiny molecules in the blood (called microRNAs) are different in people with cluster headache. It could help find better ways to diagnose or treat this condition.
PaviaAges 18–65 - NCT06540651Recruiting
Light therapy for chronic cluster headache
This study tests whether daily light therapy can reduce the number of cluster headache attacks in people with chronic cluster headache. It is a non-drug treatment that uses a special lamp to see if it helps calm your headache cycles.
MarseilleAges 18 years+ - NCT06787677Recruiting
SPG pulsed radiofrequency for chronic cluster headache
This trial tests a treatment called sphenopalatine ganglion (SPG) pulsed radiofrequency for people with chronic cluster headache. It uses short bursts of energy to calm a nerve cluster in the face that is linked to the pain, and may help when standard medicines like verapamil or lithium haven't worked.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07348783Recruiting
Yoga for chronic migraine and cluster headache
This study tests whether yoga-based movements can help reduce headache frequency and improve well-being in people with chronic migraine or cluster headache. You would follow online or in-person yoga instructions at home for several weeks, wear an activity tracker, and provide blood samples.
HuddingeAges 18–65 - NCT02910323Recruiting
Study for cluster headaches and trigeminal nerve pain
This study looks at people with certain severe headache disorders (cluster-type headaches or SUNCT/SUNA) or trigeminal neuralgia (sharp facial nerve pain). Researchers want to better understand these conditions and see how study testing/record review may help care.
Houston, TexasAges 18 years+ - NCT07113470Recruiting
Nerve stimulation for chronic cluster headache prevention
This trial tests if a device that stimulates nerves on your face and the back of your head can prevent chronic cluster headaches. It may offer a new treatment option if you have had cluster headaches for at least a year.
LeidenAges 18 years+ - NCT05477459RecruitingPhase 2
LSD treatment for reducing the burden of cluster headaches
This Phase 2 trial tests LSD to see if it can reduce how much cluster headaches disrupt your life. You may be eligible if your cluster headaches are frequent and steady, and if you meet key safety and mental-health requirements.
LeidenAges 16–75 - NCT07779486Recruiting
Intravenous magnesium for acute headache pain relief
This study compares two doses of intravenous (IV) magnesium to see which is more effective at relieving acute headache pain in the emergency department. It aims to provide a fast and effective treatment option for migraine, tension-type, or cluster headaches.
MonastirAges 18 years+ - NCT07719608Recruiting
MySalvia system for resistant migraine
This trial tests a device called MySalvia that is implanted in the head to reduce migraine attacks. It is for people whose migraines have not improved with at least three different preventive treatments.
Newnan, GeorgiaAges 22–84 - NCT07677137Recruiting
Study of a new nerve stimulation device for chronic cluster headache prevention
This study is testing a new device that uses mild electrical stimulation near the back of the head to prevent cluster headaches. It is for people with chronic cluster headaches that are hard to treat with standard medicines.
Sint-NiklaasAges 22–70 - NCT04939922Recruiting
Headache and dizziness registry for people with headache disorders
This study is a registry, meaning it collects information over time about people with headaches (including migraine, tension-type, and some dizziness-related headaches). It may help researchers better understand these conditions and plan future studies.
Hangzhou, ZhejiangAges 4–99 - NCT06277063Recruiting
Nerve-stimulation device for headache in children and young adults
This trial tests if a gentle nerve-stimulating device worn on the neck (called nVNS) can prevent and treat common headaches like migraine, cluster, and tension-type headaches in children and young adults. If you often get headaches and want a drug-free option, this might help.
Guangzhou, GuangdongAges 7–20 - NCT03511846Enrolling by invitationPhase 1
Pain biomarker study for headache or back nerve pain
This study looks at measurable “pain signals” (biomarkers) in people with certain headache disorders or lumbar nerve pain, and compares them with healthy people. It may help researchers better understand what drives pain and how it can be detected.
Houston, TexasAges 18 years+ - NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80 - NCT05324748RecruitingPhase 3
Repeated nerve-block shots for chronic cluster headache
This Phase 3 trial tests whether repeated injections can reduce attacks of chronic cluster headache. It may help people who have frequent, consistent attacks and can track them closely during the study.
LeidenAges 18–70 - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+
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Cluster Headache trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cluster headache?
- Yes. Clin2 currently lists 18 recruiting cluster headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cluster headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cluster headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.