Understanding when botulinum toxin effects wear off in neck muscle spasms
Treatments studied
Part of Brain & nervous system clinical trials.
This study looks at what happens when the effect of botulinum toxin injections (often used to treat neck muscle spasms) wears off sooner than expected. It aims to understand how the waning effect changes over time and whether switching between two brands (Botox and Dysport) might help improve how long the relief lasts.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and have been diagnosed with cervical dystonia (neck muscle spasms causing abnormal head position).
- You currently get good relief from botulinum toxin injections, but the effects wear off within 8 weeks or less.
- You have been receiving the same dose and injection pattern of Botox or Dysport for at least the last 3 treatment cycles, with a cycle length of 12 weeks.
- Your usual botulinum toxin dose is between 80 and 300 units.
- You do not have a history of swallowing difficulties, poor response to botulinum toxin, or known resistance or allergy to the treatment.
- You are not pregnant and are able to attend study visits and sign consent forms.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new botulinum toxin medication (IPN10200) for adults with cervical dystonia, a condition that causes painful muscle spasms in the neck and shoulders. It aims to see if the treatment is safe and effective in reducing symptoms.
This study tests whether combining physiotherapy with Botox injections can improve neck control in people with cervical dystonia. It also looks at how 'sensory tricks' (like touching your face) help the brain control symptoms, using brain scans to understand why.
This study tests if adding a daily pill (valbenazine) to regular botox injections can better reduce neck muscle spasms. It helps people whose botox works but may not be enough.
This trial compares using ultrasound to guide Botox injections versus the usual method without ultrasound, to see if it improves outcomes for people with cervical dystonia.
This trial studies whether a structured exercise program can help people with cervical dystonia (involuntary neck muscle tightening) who are already being treated with botulinum toxin type A. It may help improve how you move and function, alongside your usual injections.
This trial tests how a structured exercise program affects the brain and body changes behind focal cervical dystonia (a movement disorder that causes abnormal neck postures). It may help people who are still having symptoms despite best-available treatments like botulinum toxin injections or medicines.
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