Safety of nipple-sparing mastectomy for women with high-risk genes
Part of Cancer, Genetic & congenital, Hormones & metabolism clinical trials.
This study looks at the long-term safety of a type of breast surgery (nipple-sparing mastectomy) in women who carry certain inherited gene changes (BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN) that increase their risk of breast cancer. The goal is to understand how safe this surgery is over time for these women.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You were assigned female at birth.
- You are 18 years of age or older.
- You have a confirmed harmful gene change (mutation) in BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN found through genetic testing before you had any cancer symptoms.
- You have never had breast cancer.
- You have never had ovarian cancer.
- You have never had both breasts removed before your genetic testing.
- You do not have a gene change of uncertain importance without a known harmful gene change.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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