Dupilumab smell restoration study for CRSwNP
Treatments studied
Part of Brain & nervous system clinical trials.
This study tests if the medication dupilumab can improve smell loss in people with chronic sinusitis and nasal polyps. Researchers will check if blocking in the nose and electrical signals in the brain can predict who will benefit.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have documented chronic sinusitis with nasal polyps (CRSwNP).
- You have a poor sense of smell, measured by a standard smell test called BSIT.
- You have had a stable, moderate to severe smell problem for at least 3 months.
- You had sinus surgery more than 3 months ago but less than 10 years ago.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether smell training can improve your sense of smell and affect your immune system. It is for people with chronic sinus inflammation and nasal polyps who have lost their sense of smell.
This trial studies whether dupilumab can improve smell in adults whose nasal polyps are causing long-lasting smell loss. It may help learn how well the treatment restores smell, so future patients can benefit sooner.
This study looks at how dupilumab (an injection medicine) helps people with chronic rhinosinusitis with nasal polyps, including how well it works across different ethnic backgrounds. You may be able to join if you’ve been diagnosed and you can get dupilumab through insurance or a patient assistance program.
This study looks at why people with nasal polyps lose their sense of smell and how it might come back. You may be able to join if you have had nasal blockage, runny nose, smell loss, or facial pain for at least 12 weeks, have polyps seen inside your nose, and are using a steroid spray regularly.
This study tests whether dupilumab, a medication given as an injection, helps improve the lining of the nose in people with chronic sinus inflammation and nasal polyps. If you have nasal polyps and are about to start dupilumab, or if you have sinusitis without polyps, you may be eligible to join.
This trial studies whether dupilumab (an injection) can reduce staph bacteria in the nose and make the nose’s microbes more diverse in adults with chronic rhinosinusitis with nasal polyps (CRSwNP). If you already have a plan to start dupilumab as standard care, the study may help doctors better understand why it works.
Hear when a new Smell Loss trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.