Clin2
NCT06398873Possibly a fitRecruiting

Dupilumab and nasal lining in chronic sinusitis with polyps

Chronic Rhinosinusitis With Nasal PolypsChronic Rhinosinusitis Without Nasal Polyps

Treatments studied

Part of Ear, nose & throat, Immune system & allergy clinical trials.

This study tests whether dupilumab, a medication given as an injection, helps improve the lining of the nose in people with chronic sinus inflammation and nasal polyps. If you have nasal polyps and are about to start dupilumab, or if you have sinusitis without polyps, you may be eligible to join.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
80 people
Ages
18 years to 99 years
Study type
Observational

Who can take part

  • You are 18 years or older
  • You have chronic sinus inflammation (chronic rhinosinusitis)
  • If you have nasal polyps, you are planning to start treatment with dupilumab
  • You are not pregnant or breastfeeding
  • You do not have cystic fibrosis or primary ciliary dyskinesia
  • You have not had a sinus flare-up in the past 4 weeks, and you haven't taken steroid pills for your sinus condition in the past 4 weeks

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07187583Recruiting· Phase 4
Reducing biologic doses for chronic sinusitis with polyps

This trial tests if patients with chronic sinusitis and nasal polyps can safely reduce how often they take their biologic medication (dupilumab or mepolizumab) after their disease has been partly controlled for at least a year.

Aalborg
NCT07814924Recruiting· Phase 4
Mepolizumab plus in-office polyp removal for chronic sinusitis

This study tests whether combining mepolizumab (a biologic injection) with a quick in-office removal of nasal polyps improves symptoms better than usual care. It is for adults with chronic sinusitis and nasal polyps who qualify for biologic therapy.

Barakaldo
NCT07132827Recruiting· Phase 3
Study of SHR-1905 for chronic sinusitis with nasal polyps

This trial tests a new injection (SHR-1905) for people with chronic sinusitis and nasal polyps who still have symptoms despite using standard nasal spray treatments. It aims to see if the drug can reduce polyp size and improve symptoms.

Shanghai, Shanghai Municipality
NCT07520162Recruiting· Phase 3
Tezepelumab for Nasal Polyps in Chinese Adults

This study tests whether tezepelumab, a new injectable medicine, can help reduce nasal polyps and improve symptoms like nasal congestion, loss of smell, and sleep problems. You would receive the study drug while continuing your current nasal steroid spray, and your doctors would track how your symptoms change.

Beijing
NCT05094570Recruiting· Phase 4
Dupilumab for nasal polyps with staph bacteria

This trial studies whether dupilumab (an injection) can reduce staph bacteria in the nose and make the nose’s microbes more diverse in adults with chronic rhinosinusitis with nasal polyps (CRSwNP). If you already have a plan to start dupilumab as standard care, the study may help doctors better understand why it works.

Charlottesville, Virginia
NCT07268313Recruiting· Phase 4
Remission Check for Nasal Polyp Patients on Biologics

This study looks at patients with nasal polyps and chronic sinusitis who have been stable on a biologic medicine (Dupilumab or Mepolizumab) for at least 3 months. It checks if they stay in remission (symptoms well controlled, no need for extra treatments) for a full year.

Copenhagen, Region H

Hear when a new Chronic Rhinosinusitis With Nasal Polyps trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.