Clin2
NCT06899178Possibly a fitRecruiting

Atomoxetine for genetic obesity due to MC4R changes

Melanocortin Obesity SyndromeMCOS

Treatments studied

Part of Hormones & metabolism clinical trials.

This trial tests a medicine called atomoxetine (Strattera) to help people with a specific genetic form of obesity lose weight. It may be an option if you have a change in the MC4R gene and have not used certain other medications recently.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
20 people
Ages
6 years and older
Study type
Interventional

Who can take part

  • You are 6 years old or older.
  • You have a specific change in the MC4R gene linked to obesity (confirmed by a standard lab test).
  • You have obesity (BMI 30 or higher for adults, or at the 95th percentile or above for children).
  • You have not taken stimulant medications or atomoxetine in the past 30 days.
  • You have not lost more than 5% of your body weight in the last 3 months.
  • You do not have certain serious health issues like uncontrolled high blood pressure, heart rhythm problems, or severe depression.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05919797Recruiting· Phase 4
Weight loss genetics study with naltrexone and bupropion

This trial studies how your genetic makeup and body response may affect weight loss with a medication combination called naltrexone and bupropion. If you qualify, you’ll likely take these medicines and be monitored for safety and changes in weight over time.

New York, New York
NCT07674290Recruiting· Phase 4
Study of MC4R Agonist for Bardet-Biedl Syndrome and Genetic Obesity

This trial tests a drug called setmelanotide for people with Bardet-Biedl Syndrome (a rare genetic condition) or other severe genetic obesity. It looks at how well the drug works in real-world settings, not just in a lab.

Essen
NCT07725809Recruiting· Phase 1
Study of a new medicine for adults with overweight or obesity

This study tests a new medicine called PF-08653945 to see how it enters the blood in adults who are overweight or have obesity. The results will help doctors understand how the medicine works in the body.

Brussels, Bruxelles-capitale, Région de
NCT07771595Not yet recruiting· Phase 4
How atomoxetine affects motivation in healthy adults

This study tests whether a medication called atomoxetine (commonly used for ADHD) can affect motivation in healthy adults. It involves taking the medication and completing tasks to measure motivation, which could help understand how this drug works.

Oxford
NCT07142707Recruiting· Phase 1
Testing a new obesity drug for safety and effects

This study tests an investigational medication called MBX 4291 for adults with obesity. It aims to see if the drug is safe and how it works in the body, which could lead to a new weight-loss treatment option.

Doral, Florida
NCT06672549Recruiting· Phase 3
Weight loss medication study for children with obesity

This trial tests a medication for children and teens with obesity or overweight who have not been able to lose enough weight with diet and exercise alone. It aims to see if a new treatment can help them safely lose weight and improve related health problems.

Tucson, Arizona

Hear when a new Melanocortin Obesity Syndrome trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.