Bone marrow transplant for progressive multiple sclerosis
Part of Brain & nervous system, Immune system & allergy clinical trials.
This study tests whether a donor bone marrow transplant (allogeneic hematopoietic cell transplantation) can stop or slow the progression of primary progressive multiple sclerosis. It is for people with worsening symptoms who have not responded to other treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with primary progressive multiple sclerosis.
- Your disability level (EDSS score) is between 2.0 and 5.5, meaning you can walk but may need some help.
- Your multiple sclerosis has clearly worsened by at least 1 point on the disability scale in the last 4 years.
- You are willing to have your own blood stem cells collected as a backup before the transplant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how well different treatments, including bone marrow transplant, alemtuzumab, ocrelizumab, and ofatumumab, work for people with relapsing-remitting MS who have active disease. It will help doctors understand which therapy might slow disease progression best.
This trial tests if using your own stem cells can stop multiple sclerosis that keeps getting worse despite treatment. You would first receive a medication to reset your immune system, then get your stem cells back to help rebuild it.
This early-phase study tests a stem cell transplant procedure for people with multiple sclerosis whose usual MS medicines have not worked or can’t be tolerated. The goal is to see if this approach can help control MS activity and progression, while checking for safety.
This Phase 1/2 trial studies whether donated umbilical cord stem cells are safe and can improve multiple sclerosis. It aims to see if the treatment is workable for people who still have active MS despite standard therapies.
This study tests whether stem cells from donated fat tissue can slow down primary progressive multiple sclerosis. You would receive a single injection of the cells into your spinal fluid and be followed for up to 2 years.
This trial tests a new cell therapy called SYS6020 for people with multiple sclerosis that has not improved with standard treatments. The goal is to see if it can slow or stop the disease and improve symptoms.
Hear when a new Multiple sclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.