Testing hCG for acute GVHD after a stem cell transplant
Treatments studied
Part of Immune system & allergy clinical trials.
This study tests if a hormone called hCG can help treat moderate-to-severe graft-versus-host disease (GVHD) after a stem cell transplant. It is for adults who have recently developed GVHD and need steroids, but have not been on high-dose steroids for long.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have had a stem cell transplant (from a sibling or a matched unrelated donor).
- You have a new, moderate-to-severe case of graft-versus-host disease (GVHD) that needs treatment with steroids.
- You have not been on high-dose steroids for more than 3 days in the last week.
- If you or your partner could become pregnant, you are willing to use birth control or stay abstinent during the study and for 30 days after.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of a steroid and a humanized antibody (called CD25 monoclonal antibody) as the first treatment for moderate to severe acute graft-versus-host disease (aGVHD) after a stem cell transplant. The goal is to see if this combination is safer and more effective than steroids alone.
This Phase 3 trial tests whether a specific low-dose medication (methotrexate) together with standard steroid treatment can improve early outcomes in patients with acute graft-versus-host disease after a stem cell transplant. It may help control the immune reaction that attacks the body after transplant.
This study looks at whether doing moderate-to-vigorous exercise can reduce complications from corticosteroids in people with newly diagnosed GVHD. It may help your body tolerate steroids better, while checking exercise safety during treatment.
This trial tests whether giving a special type of immune-regulating cells (iMSCs) can help prevent a serious complication called graft-versus-host disease (GvHD) after a stem cell transplant. It’s for people who are at higher risk of developing GvHD based on a blood test taken a week or two after their transplant.
This trial tests whether moxibustion—a traditional Chinese medicine technique using heat from burning mugwort—can help treat acute graft-versus-host disease (a complication after bone marrow transplant) that hasn't responded to steroid drugs. If you've had a stem cell transplant and developed this condition that won't go away with standard treatment, this study may be for you.
This study tests whether special cells from your donor, called Treg cells (a type of immune cell that calms inflammation), can help treat graft-versus-host disease (GVHD) after a stem cell transplant. It is for people who have already tried other treatments but still have GVHD symptoms.
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