Stem cell injections for severe dry eye from graft-versus-host disease
Part of Eyes & vision, Immune system & allergy clinical trials.
This trial tests whether injecting stem cells around the eyes can help people with severe dry eye caused by graft-versus-host disease (GVHD) after a stem cell or bone marrow transplant. It aims to reduce eye pain and improve vision when standard treatments haven't worked.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have had graft-versus-host disease (GVHD) with severe dry eye in both eyes for more than 3 months
- You have tried at least 3 months of standard eye treatments like artificial tears, blood-derived drops, insulin drops, or cyclosporine/tacrolimus eye drops
- You still have severe symptoms despite using lubricating eye drops at least 4 times a day
- You are not pregnant and agree to use contraception during the trial
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an eye drop solution for people with chronic dry eye caused by graft-versus-host disease after a stem cell transplant. It aims to see if the drops can reduce eye discomfort and improve the eye surface.
This trial studies special stem cell lenses placed on the eye to treat chronic graft-versus-host disease (cGVHD) that causes dry, irritated eyes. It may help if standard eye treatments haven't worked well.
This trial tests if gentle electrical stimulation around the eye can help relieve dry eye symptoms caused by chronic graft versus host disease (a complication after a stem cell or bone marrow transplant). It is for people with moderate to severe dry eye who have not had recent eye surgeries or certain other eye problems.
This study looks at how common and how severe corneal nerve-related dryness is in people with chronic graft-vs-host disease (GVHD) after a stem cell transplant. It may help doctors understand which eye problems are most typical and how best to recognize them early.
This early-stage trial tests whether special cells derived from umbilical cord tissue can help treat dry eye disease. The treatment uses tiny particles called extracellular vesicles that may reduce eye dryness and improve comfort.
This study tests whether a new eye drop (rhPRG4) can safely reduce dry eye symptoms caused by graft-versus-host disease (GVHD). It compares the active drops to an inactive placebo to see if they provide better relief.
Hear when a new Dry Eye Disease (DED) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.