Clinical trials
Dry Eye Disease (DED) clinical trials
Below are recruiting dry eye disease (ded) clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07780890Recruiting
Measuring eye hydration with light
This study uses a non-invasive imaging technique called Brillouin hydration mapping to measure hydration levels in different parts of the eye. It aims to help doctors better understand how hydration affects eye health and disease.
Boston, MassachusettsAges 20–79 - NCT07659626Recruiting
Long-term effects of Acoltremon for dry eye disease
This study tests a new medication called Acoltremon to see if it helps dry eye symptoms over a long period. If you've had dry eye for a while and used artificial tears, this trial might be for you.
Louisville, KentuckyAges 18 years+ - NCT07430735Recruiting
Moisture chamber glasses for dry eye relief
This trial tests a special pair of glasses that create a moisture chamber to relieve dry eye symptoms. It is for adults with mild to moderate dry eye who already wear glasses.
Rochester, New YorkAges 18 years+ - NCT05865379Recruiting
Tested eye drops for dry eye relief and safety
This trial studies whether BUFY01 eye drops work better than SVS20 for treating dry eye disease. You may be able to join if you have dry eye symptoms for at least 3 months and meet eye exam score and tear-test requirements.
ParisAges 18 years+ - NCT07571330Recruiting
Upper Tear Drain Plug for Dry Eye After Lower Plug
This trial tests whether adding a plug to your upper tear drain (in addition to an existing lower plug) helps severe dry eye. It may improve comfort by reducing tear loss.
Monterrey, Nuevo LeónAges 18 years+ - NCT07745062RecruitingPhase 4
Comparing two eye drops for mild to moderate dry eye
This study tests two types of preservative-free eye drops to see which is more effective for people with mild to moderate dry eye disease. You will use one of the drops as directed, and the study will monitor your symptoms and eye health over time.
La Jolla, CaliforniaAges 18 years+ - NCT07732010RecruitingPhase 4
Tryptophan for dry eye disease
This trial tests whether a dietary supplement called TRYPTYR can improve dry eye symptoms. You may qualify if you have moderate dry eye with certain signs, like short tear breakup time and staining on your eye surface.
New York, New YorkAges 18 years+ - NCT07453212Enrolling by invitation
Food supplement for dry eye caused by meibomian gland issues
This trial tests a food supplement designed to improve dry eye symptoms by targeting the microbiome. It may help if you have dry eye due to meibomian gland problems and are not using contact lenses or certain other eye treatments.
IstanbulAges 18–65 - NCT07413172RecruitingPhase 2
Testing serum tears for severe dry eye
This study tests whether eye drops made from your own blood serum (with a natural lubricant) can relieve moderate-to-severe dry eye better than a standard salt solution. If you have dry eye from certain immune conditions or nerve damage, this may help find a more effective treatment.
Miami, FloridaAges 18 years+ - NCT05605314Recruiting
Study different types of dry eye in Sjögren’s
This study looks at patients with Sjögren’s-related dry eye to understand how different subtypes affect tear function and eye symptoms. It may help doctors better sort out dry eye types, which can guide more tailored care.
BeijingAges 18–80 - NCT05865457Recruiting
Testing two eye treatments for dry eye symptoms
This trial compares two different dry-eye eye drops to see which works better and is safe. You may be able to join if you’ve had dry eye for at least 3 months and meet specific eye-test results.
GrazAges 18 years+ - NCT06543303RecruitingPhase 2
Testing BTV100 for moderate to severe dry eye
This trial tests BTV100, an investigational eye drop, for people with ongoing moderate to severe dry eye disease. It aims to see if the treatment can improve dryness and discomfort.
Doncaster East, VictoriaAges 18 years+ - NCT06615453Recruiting
Tixel treatment for dry eye disease and periorbital wrinkles
This study tests a device called Tixel that may help reduce wrinkles around the eyes and improve dry eye symptoms. If you have mild to moderate under-eye wrinkles and dry eyes that bother you a lot, this treatment might be an option.
BirminghamAges 18 years+ - NCT06655441RecruitingPhase 4
Trehalose eye drops for dry eye disease
This study tests if a special sugar-based eye drop called trehalose can improve the protective layer of the eye in people with moderate to severe dry eye. It might help strengthen the cornea and reduce discomfort.
Fullerton, CaliforniaAges 18 years+ - NCT06696625Recruiting
Nerve stimulation for dry eye relief
This trial tests if mild electrical pulses on the ear can reduce dry eye symptoms. If you have had dry eye for at least 6 months and meet certain eye test results, this non-drug treatment might help.
Beijing, Beijing MunicipalityAges 18–65 - NCT06841471Recruiting
Role of Corneal Nerves in Dry Eye Disease
This study looks at how the nerves in the front of the eye (corneal nerves) relate to dry eye disease. It compares people with dry eye to those without to understand differences.
OltenAges 18 years+ - NCT06879782RecruitingPhase 3
Eye drops for dry eye disease: a phase 3 study
This study tests an eye drop called lifitegrast for people with dry eye disease. It looks at whether the drops can improve eye comfort, reduce dryness, and help eye surface health. You may be able to join if you have had dry eye symptoms and used artificial tears in the past month.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06898853Recruiting
Eye drops for dry eye: A 12-week study
This trial tests whether an anti-inflammatory eye drop (ciclosporin A) can help dry eyes by changing immune cells on the eye's surface. It lasts 12 weeks and may be an option for people with moderate to severe dry eye.
Sydney, New South WalesAges 18 years+ - NCT06984549Recruiting
Dry eye detection via smartphone camera
This study tests if a smartphone can take clear pictures and videos of your eyes to help doctors check for dry eye disease. It may be a simpler way to evaluate dryness from home.
Wenzhou, ZhejiangAges 18 years+ - NCT07155057Recruiting
Dry eye gel for cataract surgery patients
This study tests a gel placed into the tear drain to treat dry eye in people who are also getting cataract surgery. You may be able to join if you have dry eye and are having cataract surgery.
Sioux Falls, South DakotaAges 22 years+ - NCT07175909Recruiting
Tear analysis for dry eye diagnosis and management
This study looks at proteins in your tears to better understand and treat dry eye disease. You may qualify if you have dry eye symptoms and certain test results show your eyes are not functioning normally.
Hong KongAges 18–65 - NCT07266948RecruitingPhase 4
How TRYPTYR eye drops affect dry eye symptoms and daily life
This study tests a new eye drop called TRYPTYR to see if it can improve quality of life and daily tasks for people with dry eye disease who are unhappy with their current treatment, Restasis. Participants will stop using Restasis and switch to TRYPTYR for about 4 weeks.
Pittsburg, KansasAges 18–75 - NCT07396441RecruitingPhase 4
Kelulut honey therapy for juvenile glaucoma
This trial tests if adding Kelulut honey to standard treatment can help protect the optic nerve in young people with juvenile open-angle glaucoma. It looks at eye pressure, nerve thickness, and dry eye symptoms.
Kota Bharu, KelantanAges 15–40 - NCT07676084RecruitingPhase 4
Over-the-counter lubricating eye drops for dry eye
This study tests whether over-the-counter lubricating eye drops can improve dry eye symptoms and eye comfort. It compares the drops to no treatment to see how well they work.
Andover, MassachusettsAges 18 years+
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Dry Eye Disease (DED) trials by city
Studies with a site in or near these metro areas.
Dry Eye Disease (DED) trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for dry eye disease (ded)?
- Yes. Clin2 currently lists 39 recruiting dry eye disease (ded) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a dry eye disease (ded) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a dry eye disease (ded) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.