Comparing metformin and berberine for type 2 diabetes based on genetics
Part of Hormones & metabolism clinical trials.
This study compares two common diabetes treatments – metformin and a natural supplement called berberine – to see which works better for people with a specific genetic type. If you qualify, you’ll receive one of these treatments to help control your blood sugar.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 30 to 65 years old.
- You were diagnosed with type 2 diabetes in the last 12 months.
- Your latest HbA1c (a blood sugar average test) is between 7.0 and 9.0% (53–75 mmol/mol).
- You have never taken diabetes pills, or you’ve taken them for less than 4 weeks.
- You have one of two specific genetic types (TT or CC) of the TCF7L2 gene – you’ll be tested for this.
- You are not pregnant, breastfeeding, have no serious liver/kidney/heart disease, and are not allergic to metformin or berberine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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