Study of LY4298445 for Lupus and Rheumatoid Arthritis
Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.
This trial tests a new drug called LY4298445 in healthy people and those with lupus or rheumatoid arthritis. It aims to see if the drug is safe and how the body processes it.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Healthy participants must be 18 to 55 years old, weigh at least 50 kg, and have a BMI between 18 and 32.
- People with lupus must be 18 to 75 years old, weigh between 45 and 145 kg, and have a BMI between 18 and 35. They must have been diagnosed with lupus for at least 6 months using standard criteria.
- People with rheumatoid arthritis must be 18 to 75 years old, weigh between 45 and 145 kg, and have a BMI between 18 and 35. They must have had RA for at least 6 months and have moderate to high disease activity.
- People with RA must have tried and failed at least 2 advanced treatments (like biologics) after trying a conventional DMARD.
- You cannot join if you have severe lupus kidney disease, active lupus affecting the brain, or certain severe forms of RA.
- Pregnant or breastfeeding women cannot take part.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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