Short-course radiation plus immunotherapy and chemo before rectal cancer surgery
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a new combination of short-course radiation, an immunotherapy drug called ivonescimab, and chemotherapy given before surgery for locally advanced rectal cancer. The goal is to see if this approach helps shrink the tumor and improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You need to be in good enough health to carry out daily activities (ECOG score 0 or 1).
- You must have a type of rectal cancer that has not spread to distant organs (stage II or III).
- Your tumor must have a specific protein marker called pMMR or MSS, which is found by a biopsy.
- You cannot have had any prior treatment for rectal cancer, such as chemotherapy, radiation, or surgery.
- You must not have other serious medical conditions or active infections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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