Drug-coated balloon for non-blocking heart plaque after a heart attack
Part of Heart & circulation clinical trials.
This study is testing a special balloon that releases a drug (sirolimus) to treat fatty plaques in heart arteries that are not yet blocking blood flow. The hope is that this treatment can stabilize or even shrink these plaques, reducing future risk of heart attacks. If you have recently had a heart attack and have other non-obstructive plaques, this trial might offer a new approach.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have had a heart attack or another acute heart event in the last 90 days and have had the main blockage treated with a procedure like angioplasty or stenting.
- You must have at least two other narrowed areas in different heart arteries that are not causing symptoms (not blocking blood flow enough to be considered severe).
- Your doctor must confirm these non-blocking areas are fatty deposits that can be measured with a special imaging test (called IVUS-NIRS) during a catheter procedure.
- You must be 18 years or older and able to give informed consent.
- You cannot have certain risky locations for these other narrowings (like the left main artery or at the opening of a major artery), or have had a stent placed in the same area, or have the narrowing in a bypass graft.
- You cannot have very severe kidney disease (on dialysis or with very low kidney function), be pregnant or breastfeeding, have a life expectancy under 2 years from other conditions, or be in another research study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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