Gut bacteria as an early sign of knee damage or infection
Part of Bones, joints & muscles, Infections clinical trials.
This study looks at the bacteria in your gut (the microbiome) as a possible early sign of knee osteoarthritis or joint infection. If you're having a knee replacement or a revision and are between 18 and 50, your participation could help find new ways to diagnose and prevent joint problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 50 years old.
- You need to have a 'gut dysbiosis' — an imbalance in the bacteria living in your gut — that's been confirmed by a test.
- You must be scheduled for a total knee replacement, or a revision of a previous knee or hip replacement due to infection or loosening.
- You cannot have any current or past joint symptoms, or previous shoulder or knee surgery or joint disease.
- You cannot have taken antibiotics in the last 6 months, have severe obesity (BMI over 40), or have inflammatory bowel disease (like Crohn's or ulcerative colitis).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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