Comparing three antibiotic strategies for joint replacement infections
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This study is testing whether giving three different antibiotic combinations (instead of one) before surgery can better protect the good bacteria in your gut and reduce the chance of developing resistant bacteria. If you are having a joint replacement revision or similar surgery due to a suspected infection, participation might help improve how infections are treated.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are scheduled for a revision (replacement) of a hip, knee, or other joint prosthesis, or for internal fixation surgery, and your doctor suspects a bone or joint infection.
- You have not taken any antibiotics in the last 3 months.
- You have a normal level of CPK (an enzyme found in muscle) in your blood.
- You do not have chronic inflammatory bowel disease or have not had surgery to remove part of your small intestine or colon.
- You are not allergic to certain antibiotics (daptomycin, cefepime, piperacillin/tazobactam, or ceftobiprole).
- Your kidney function is adequate (not below 50 mL/min/1.73 m²).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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