Study on antibiotics and gut bacteria in joint replacement infections
Part of Bones, joints & muscles, Infections clinical trials.
This trial tests how different antibiotic combinations affect the bacteria in your gut and the risk of infection with hard-to-treat bacteria. It is for people who need surgery for a joint replacement or bone infection.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You need surgery to replace a joint (hip, knee, shoulder, elbow) or fix a bone infection.
- You have not taken antibiotics in the last 3 months.
- You do not have active signs of infection like draining wounds, abscesses, or bacteria in your joint fluid.
- You do not have inflammatory bowel disease or missing parts of your small intestine or colon.
- You are not allergic to certain antibiotics (daptomycin, cefepime, piperacillin-tazobactam, ceftobiprole) or other penicillins.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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