KarXT for mania in bipolar I disorder
Treatments studied
Part of Brain & nervous system clinical trials.
This study tests a new medication called KarXT to see if it helps calm manic episodes in people with bipolar I disorder. You would need to be in the hospital for a manic episode and stop other psychiatric medications temporarily.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of bipolar I disorder (manic episodes).
- You are currently in a manic or mixed episode that started within the last 3 weeks.
- You need to be in the hospital for this manic episode.
- You have not taken any psychiatric medications for up to 2 weeks before the study starts.
- You do not have a history of rapid cycling (4+ mood episodes per year) or other major mental health conditions except mild anxiety.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new medicine (KarXT) for schizophrenia, focusing on how it affects urological (bladder and urinary) safety. You'll stop your current antipsychotic and take the study drug to see if it works well and is safe for your urinary system.
This trial looks at how well KarXT works and what side effects it might have when people with schizophrenia switch to it from their current antipsychotic medication. It may be an option for those who have started KarXT recently or who plan to switch from their current treatment.
This trial tests a new medicine, KarXT, to see if it can safely treat manic episodes in people with bipolar I disorder. It is for patients who are currently hospitalized for a manic episode that started within the last 3 weeks.
This study tests whether adding KarXT to lithium, valproate, or lamotrigine helps calm manic episodes in people with bipolar I disorder. It aims to see if the combination is safe and works better than the mood stabilizer alone.
This study tests the long-term safety of KarXT for people with bipolar I disorder who are having a manic or mixed episode. It is for people who either completed a previous KarXT study or are new to the study and have moderate to severe mania symptoms.
This trial tests a new medication called KarXT for people with schizophrenia who are currently having a psychotic episode. It is for Japanese adults who have had schizophrenia before and are not in their first episode.
Hear when a new Bipolar Disorder Type I With Mania or Mania With Mixed Features trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.