Clin2
NCT06967103Possibly a fitRecruiting

New drug before breast cancer surgery

Breast CancerHR+/HER2- Breast Cancer

Treatments studied

Part of Cancer, Skin clinical trials.

This trial tests a new drug, QL1706, given alongside chemotherapy before surgery for a certain type of breast cancer. It aims to see if this combination helps shrink tumors before they are removed.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
238 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are a woman aged 18 or older and are scheduled to have surgery for breast cancer.
  • Your breast cancer is hormone receptor-positive (HR+) and HER2-negative, with a high Ki67 score (≥20%).
  • You have not had any previous chemotherapy, radiation, or other cancer drugs for this breast cancer.
  • Your tumor is stage cT2-T4d with or without lymph node involvement, or it is stage cT1c with confirmed spread to lymph nodes.
  • Your overall health is good (ECOG score 0-1) and your organs are functioning well enough for treatment.
  • You are willing to provide a tumor tissue sample and use effective birth control if you are premenopausal.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07136974Not yet recruiting· Phase 2
New drug combo for HER2-positive breast cancer before surgery

This trial tests a new drug called TQB2102 combined with standard chemotherapy (TCbHP) as a first treatment before surgery for HER2-positive early breast cancer. The goal is to see if this combination works better than the current standard therapy.

Zhengzhou, Henan
NCT06404463Not yet recruiting· Phase 2
New drug plus chemo before surgery for early breast cancer

This trial tests a new drug called QL1706 combined with chemotherapy given before surgery for people with early-stage, high-risk breast cancer that is estrogen receptor positive (ER+) and HER2 negative. The goal is to see if this combination can shrink tumors more effectively before surgery.

NCT07246317Not yet recruiting· Phase 2
Testing a new drug combo for early HER2+ breast cancer before surgery

This trial tests a combination of targeted therapies (trastuzumab and pertuzumab) with chemotherapy (docetaxel) and an experimental drug (QL1706) given before surgery to shrink early or locally advanced HER2-positive breast cancer. It aims to see if this approach improves outcomes before definitive surgery.

Guangzhou, Guangdong
NCT06441890Recruiting· Phase 2
Personalized chemo before breast cancer surgery

This trial tests whether giving chemotherapy before surgery, guided by the genetic profile of your tumor, can improve outcomes for a specific type of HER2-positive breast cancer. It aims to tailor treatment to each person's cancer biology.

Chicago, Illinois
NCT07372079Not yet recruiting· Phase 2
Immunotherapy plus chemo before surgery for early triple-negative breast cancer

This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy before surgery for early-stage triple-negative breast cancer. It aims to see if the treatment shrinks the tumor enough to make surgery more effective.

Tianjin
NCT07300215Not yet recruiting· Phase 2
Personalized treatment before surgery for early HR+/HER2+ breast cancer

This trial tests whether a customized treatment plan given before surgery can improve outcomes for women with early-stage HR-positive, HER2-positive breast cancer. The goal is to shrink the tumor and make surgery more effective.

Hear when a new Breast cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.