High-dose topotecan for retinoblastoma with vitreous seeds
Treatments studied
Part of Cancer, Eyes & vision clinical trials.
This trial tests a high dose of a chemotherapy drug called topotecan given directly into the eye (intravitreal injection) for children with retinoblastoma that has come back or not responded to treatment and has seeds floating in the vitreous. The goal is to save the eye when removal is the only other option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must be between 1 and 12 years old.
- The retinoblastoma must have come back or not gotten better after previous treatments, with seeds in the vitreous (the jelly inside the eye).
- Doctors have recommended removing the eye, but you want to try to save it.
- Your child's kidneys, liver, and blood counts must be in a normal range.
- Your child should not have other serious health problems like uncontrolled seizures, heart disease, active infections, or a weakened immune system.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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