Clinical trials
Retinoblastoma clinical trials
Below are recruiting retinoblastoma clinical trials, each written for real people, not researchers. We’re tracking 20 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05504291RecruitingPhase 2
Treatment delivered inside the eye for retinoblastoma
This Phase 2 study tests a way to deliver cancer treatment directly inside the eye to treat retinoblastoma. It may help shrink the tumor while limiting treatment to the eye when possible.
Birmingham, AlabamaAges Up to 18 years - NCT06725173Recruiting
Retinoblastoma genetics and tumor spread study
This study looks at gene changes in retinoblastoma to understand why some tumors spread outside the eye. It may help find better ways to predict and treat the disease.
Seattle, WashingtonAges Any age - NCT03932786Recruiting
Study of health and wellbeing after retinoblastoma treatment
This study looks at long-term health outcomes—how patients are doing physically and in daily life—after treatment for retinoblastoma. It may help doctors understand what support or follow-up care could be most helpful after treatment.
Chicago, IllinoisAges Any age - NCT04959097Recruiting
CHLA retinoblastoma database and tissue study
This study collects medical information and, when available, tissue samples from children with retinoblastoma treated at Children’s Hospital Los Angeles. It may help doctors learn more about the disease and improve future care.
Phoenix, ArizonaAges birth–18 years - NCT06367530Recruiting
Trilateral retinoblastoma: incidence and outcomes
This study looks at how often trilateral retinoblastoma (a rare form that affects the brain as well as the eye) happens and what the outcomes are. It may help doctors better understand this condition.
Amsterdam, North HollandAges Any age - NCT05650749Enrolling by invitationPhase 1
GPC2 car T cells for neuroblastoma and retinoblastoma
This trial tests a new treatment using engineered immune cells (CAR T cells) that target a protein called GPC2 found on some cancer cells. It is for patients with high-risk neuroblastoma or metastatic retinoblastoma that has returned or not responded to other treatments.
Philadelphia, PennsylvaniaAges 1 year+ - NCT03546387Recruiting
Anesthesia and brain thinking changes in children with retinoblastoma
This study looks at whether having anesthesia more than once (for eye/surgery treatment) affects children’s thinking and learning. It may help doctors plan safer care and better follow-up for children with retinoblastoma.
New York, New YorkAges 6–17 - NCT06972602RecruitingEarly Phase 1
High-dose topotecan for retinoblastoma with vitreous seeds
This trial tests a high dose of a chemotherapy drug called topotecan given directly into the eye (intravitreal injection) for children with retinoblastoma that has come back or not responded to treatment and has seeds floating in the vitreous. The goal is to save the eye when removal is the only other option.
Shanghai, ChinaAges 1–12 - NCT03662776Enrolling by invitation
How past eye-cancer treatment affects survivors’ well-being
This study looks at how different treatments for one affected eye retinoblastoma may affect survivors’ emotional and social functioning. It may help doctors understand which treatment approaches are linked with better day-to-day well-being over time.
New York, New YorkAges 8–17 - NCT03267459Recruiting
MRI test before treatment to predict chemotherapy response
This trial looks at whether an MRI scan done before treatment can help predict how well intra-arterial chemotherapy will work for retinoblastoma. If you qualify, your MRI results may help doctors estimate your response and guide care.
ParisAges Any age - NCT04425434Recruiting
Treatment plan study for children with retinoblastoma
This trial looks at care recommendations for children with retinoblastoma (a childhood eye cancer). It may help standardize the best treatment approach for different patterns of tumor spread.
OuagadougouAges Up to 18 years - NCT04681417RecruitingPhase 2/Phase 3
Eye-sparing treatment options for children with retinoblastoma
This trial studies whether newer “save-the-eye” treatment plans can control retinoblastoma (eye cancer) while keeping vision as good as possible. It compares different conservative treatment strategies depending on how the tumor looks and where it is.
Saint-Denis, La RéunionAges 6 months–6 years - NCT04799002RecruitingPhase 3
Topotecan and melphalan for eye-sparing retinoblastoma treatment
This trial studies whether a combination chemotherapy treatment (topotecan plus melphalan) can help children with retinoblastoma while keeping the eye when possible. It’s a Phase 3 study, meaning it’s testing effectiveness in a larger group of patients.
Guangzhou, GuangdongAges Any age - NCT04903678Recruiting
Chemo into spinal fluid for advanced retinoblastoma spread
This trial studies giving chemotherapy directly into the spinal fluid to treat retinoblastoma that has spread to the central nervous system (brain/spinal cord). It may help by targeting tumor cells that are in the fluid around the brain and spinal cord.
ShanghaiAges Any age - NCT05080010RecruitingPhase 3
Extra chemo after eye removal for high-risk retinoblastoma
This Phase 3 study tests whether giving chemotherapy after the eye has been removed can lower the chance of retinoblastoma coming back for children with high-risk disease. You may be screened if your child had one eye affected and meet the staging and treatment history requirements.
Guangzhou, GuangdongAges Any age - NCT06424301RecruitingEarly Phase 1
Targeted gene therapy for hard-to-treat retinoblastoma
This trial tests an experimental drug that targets a specific gene (NUDT21) to treat retinoblastoma that has not responded to standard treatments. It is for children who have active tumor in only one eye and whose only other option is to remove the eye, but who want to try to save the eye instead.
ShanghaiAges 6 months+ - NCT06679634RecruitingPhase 2
Topotecan eye patch for retinoblastoma
This trial tests a new way to deliver the chemotherapy drug topotecan directly to the eye (via a small patch placed on the eye surface) for children with retinoblastoma that either needs eye removal or has come back after standard treatment. It aims to see if this approach can help save the eye and vision.
New York, New YorkAges Up to 8 years - NCT06227962Enrolling by invitation
Thinking and quality of life in retinoblastoma survivors
This study looks at how retinoblastoma and its treatment affect thinking skills and quality of life over time. It may help doctors better support survivors and their families.
Amsterdam, North HollandAges 6 months–35 years - NCT03050268Recruiting
Study of childhood cancer risk in families
This study looks at inherited (family) risk for childhood cancers, including families with early cancers or known cancer risk conditions. It may help researchers understand why some children get cancer and improve future risk detection and care.
Memphis, TennesseeAges Any age - NCT01109394Recruiting
Help study tumors with sample testing and a research biology library
This study collects tumor (or related) samples to analyze their genes and build a shared research “biobank.” It may help researchers understand cancers better for future diagnosis and treatments.
Washington D.C., District of ColumbiaAges 4 weeks+
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Retinoblastoma trials by city
Studies with a site in or near these metro areas.
Retinoblastoma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for retinoblastoma?
- Yes. Clin2 currently lists 20 recruiting retinoblastoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a retinoblastoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a retinoblastoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.