Dialysis intensity for high ammonia in liver failure
Part of Digestive system, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests if a higher intensity of continuous dialysis (CRRT) better lowers ammonia levels in patients with liver failure. It aims to find the best approach to reduce brain complications from high ammonia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older
- You have acute or acute-on-chronic liver failure with high ammonia levels (over 72 or 100 μmol/L, depending on symptoms)
- You have signs of confusion or brain effects (hepatic encephalopathy grade 2 or higher, or ammonia over 100)
- Your medical team has decided that continuous dialysis (CRRT) is needed
- You are not pregnant
- You do not have liver failure from severe low blood pressure or from liver injury caused by lack of blood flow
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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