Genetic risk screening study for hereditary cancer syndromes
Part of Blood & lymphatic, Bones, joints & muscles, Cancer, Genetic & congenital, Hormones & metabolism, Skin clinical trials.
This study screens individuals who may have a genetic condition that increases cancer risk. It looks for certain inherited syndromes, like Li-Fraumeni syndrome, RASopathies, or bone marrow failure syndromes, and helps determine if further genetic testing or cancer monitoring is needed.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You or a family member has had cancer or tumors that seem unusual, multiple, or at a young age.
- You or a family member has been diagnosed with a genetic syndrome linked to cancer, such as Li-Fraumeni, Noonan syndrome, or Fanconi anemia.
- You or a family member carries a genetic change (variant) in a gene associated with cancer risk, like TP53, RAS pathway genes, or DICER1.
- You or a family member has had certain rare tumors like adrenal cortical carcinoma, choroid plexus carcinoma, pleuropulmonary blastoma, chordoma, or melanoma at a young age.
- You or a family member has a condition like bone marrow failure, such as dyskeratosis congenita or severe congenital neutropenia, with or without a known genetic cause.
- No prior genetic testing is required; even if you haven't had testing, you can participate if you meet the clinical criteria.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at people with certain inherited genetic conditions called RASopathies and their family members. It helps researchers understand these conditions and how genetic changes run in families, which may improve future care.
This study collects medical and genetic information to better understand how often cancer develops in people with Li-Fraumeni syndrome and related family risks. It may help families and doctors plan earlier awareness and follow-up over a person’s lifetime.
This study looks at inherited (family) risk for childhood cancers, including families with early cancers or known cancer risk conditions. It may help researchers understand why some children get cancer and improve future risk detection and care.
This study collects and stores health samples and information from people with RASopathy conditions (like Noonan or Costello syndromes) and from family members who may not have the condition. It helps researchers understand these disorders and supports future studies that could lead to better care.
This study looks at people who have a RASopathy—a genetic condition—and also have solid tumors (tumor growths not in blood). To join, your RASopathy must be confirmed by genetic testing, not only by symptoms.
This study is looking at how people in families with certain TP53 gene changes (including Li-Fraumeni syndrome) develop health problems over time. It may help doctors better understand risk and improve care for affected families.
Hear when a new Melanoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.