PRP vs. hyaluronic acid for advanced knee arthritis
Part of Bones, joints & muscles, Pain clinical trials.
This study compares two treatments—platelet-rich plasma (PRP) and hyaluronic acid (a lubricating injection)—for people with severe knee arthritis seen on MRI. The goal is to see which better reduces pain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- You have severe knee arthritis (grade III or IV) confirmed by MRI in one knee only
- Your knee pain is at least 3 out of 10 on a pain scale
- Your body mass index (BMI) is less than 35
- You have not had certain anti-inflammatory drugs or steroid injections recently (your doctor will check specifics)
- You are not on a blood thinner that cannot be paused for treatment injections
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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