Medication study for depression with brain scans
Part of Mental health clinical trials.
This study tests whether a targeted medication can improve mood and brain function in adults with major depression. If you qualify, you'll receive a study drug and have fMRI brain scans to see how your brain responds.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 65 years old
- You have current or past major depression (diagnosed by a doctor)
- You are not taking any psychiatric medications (or are willing to stop under a doctor's supervision)
- You can safely have an fMRI brain scan (no metal implants, pacemaker, etc.)
- You do not have current ADHD, bipolar disorder, OCD, eating disorder, or recent substance use
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a personalized approach to treating major depressive disorder using assessments and brain imaging to match you with the best therapy. It aims to improve outcomes by tailoring care to your specific needs.
This study looks at changes in depression “markers” to understand what treatments help and why. You’ll have non-invasive brain stimulation and scans before and after treatment, over about 8 weeks.
This study uses brain scans (MRI) to understand how people with depression process rewards, aiming to identify different depression subtypes. You may join if you have depression or if you are a healthy volunteer.
This study tests how a medication called memantine affects memory and mood in people with major depression who are not currently taking antidepressants. It involves MRI scans and may help find new ways to treat depression.
This Phase 1 study uses a PET brain scan tracer to see how a specific brain target (PDE4B) is involved in major depressive disorder (MDD). It’s mainly testing whether the imaging approach works and what it shows in people with depression who meet specific safety and medication rules.
This trial studies a way to change how excitable the brain is (through in-person brain stimulation) in people with major depression. It may help understand new treatments or symptom patterns that could be useful for major depression.
Hear when a new Depression - Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.