Clin2
NCT07028918Possibly a fitNot yet recruiting

Low-dose radiation with immunotherapy and chemo for oral cancer

Oral Squamous Cell Carcinoma (OSCC)

Part of Cancer clinical trials.

This trial is testing a combination of low-dose radiation, immunotherapy, and chemotherapy for people with advanced oral cancer that hasn't been treated before. The goal is to see if this approach can help control the cancer and possibly improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
35 people
Ages
18 years to 70 years
Study type
Interventional

Who can take part

  • You are between 18 and 70 years old.
  • You have been diagnosed with oral squamous cell carcinoma (a type of mouth cancer).
  • Your cancer is stage III or IVA or IVB, and it has not spread to other parts of your body.
  • You have not received any previous cancer treatment, such as surgery, radiation, chemotherapy, or immunotherapy.
  • You are in generally good health, with adequate organ function (like blood counts, liver, and kidney function).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07137858Not yet recruiting· Phase 2
Immunotherapy plus chemotherapy before surgery for advanced oral cancer

This trial tests a combination of an immunotherapy drug (adebrelimab) and two standard chemotherapy drugs (carboplatin and albumin-bound paclitaxel) before surgery for advanced oral cancer that can be removed. The goal is to see if this approach helps shrink the tumor and improve outcomes.

NCT06861712Not yet recruiting· Phase 2
Chemoimmunotherapy with or without radiation before surgery for advanced mouth and throat cancer

This trial tests whether adding a type of radiation therapy (SBRT) to chemoimmunotherapy before surgery helps people with advanced mouth or throat cancer. The goal is to see if this combination can shrink tumors more effectively and improve outcomes.

Guangzhou, Guangdong
NCT07371611Recruiting· Phase 3
Sintilimab plus chemo before and after surgery for advanced oral cancer

This trial tests whether adding an immunotherapy drug (sintilimab) to standard chemotherapy before and after surgery can improve outcomes for people with advanced oral squamous cell carcinoma. The treatment is given first to shrink the tumor, then again after surgery to help prevent recurrence.

Guangzhou, Guangdong
NCT07827872Not yet recruiting· Phase 3
Immunotherapy plus chemotherapy before surgery for oral cavity cancer

This trial tests whether giving immunotherapy (sintilimab) together with chemotherapy before surgery can help treat oral cavity cancer. The goal is to shrink the tumor and possibly improve outcomes for patients with early-stage cancer that hasn't spread.

Guangzhou, Gyangdong
NCT07514767Not yet recruiting· Phase 2
Immunotherapy before surgery for mouth cancer

This trial tests an immunotherapy drug called nivolumab given before surgery for mouth cancer. The goal is to see if it can shrink the tumor and improve outcomes after surgery.

Stockholm
NCT07007364Recruiting· Phase 2
Testing low-dose radiation with immunotherapy and chemo for early oral cancer

This trial tests if combining a low dose of radiation with an immunotherapy drug (adebrelimab) and a chemotherapy drug (albumin-bound paclitaxel) before surgery can help treat early-stage oral squamous cell carcinoma. It aims to see if this combination is safe and effective.

Wuhan, Hubei

Hear when a new Oral Squamous Cell Carcinoma (OSCC) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.