Immunotherapy plus chemotherapy before surgery for oral cavity cancer
Treatments studied
Part of Cancer, Mouth & dental clinical trials.
This trial tests whether giving immunotherapy (sintilimab) together with chemotherapy before surgery can help treat oral cavity cancer. The goal is to shrink the tumor and possibly improve outcomes for patients with early-stage cancer that hasn't spread.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have been diagnosed with squamous cell carcinoma of the mouth (oral cavity).
- Your cancer must be at a specific early stage (cT2N0M0), meaning it is a certain size but has not spread to lymph nodes or other parts of the body.
- You must be between 18 and 75 years old.
- You must be well enough to take part (ECOG performance status 0 or 1) and have adequate organ function.
- You must be eligible for surgery to remove the tumor and nearby lymph nodes.
- You must not have had prior chemotherapy, radiation, or immunotherapy for head and neck cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This trial tests whether adding an immunotherapy drug (sintilimab) to standard chemotherapy before and after surgery can improve outcomes for people with advanced oral squamous cell carcinoma. The treatment is given first to shrink the tumor, then again after surgery to help prevent recurrence.
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This trial tests whether giving tislelizumab (an immunotherapy) with chemotherapy before surgery works better than surgery alone for people with head and neck cancer that has not spread to lymph nodes. It's for cancers that can be removed with surgery, and the goal is to see if the pre-surgery treatment improves outcomes.
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