Spermidine to prevent dry mouth from radiation therapy
Part of Cancer, Ear, nose & throat clinical trials.
This trial tests whether spermidine (a natural compound) can help prevent dry mouth caused by radiation treatment for head and neck cancer. It is for patients who will receive a significant dose of radiation to their saliva glands.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 80 years old and have head and neck squamous cell cancer (including nasopharyngeal cancer).
- You are about to receive radiation therapy (alone or with chemo) that will deliver at least 25 Gy to your parotid glands.
- You have adequate blood counts (hemoglobin, platelets, white blood cells).
- You do not have a history of dry mouth, Sjögren's syndrome, or other conditions causing dry mouth.
- You are not allergic to wheat or gluten.
- You have not had radiation to the head and neck before, and you are not taking certain medications that affect saliva production.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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