Limonene gelcaps with radiation and chemo to prevent dry mouth
Treatments studied
Part of Mouth & dental clinical trials.
This Phase 1 study tests whether a citrus-flavored supplement (d-limonene gelcaps) can help prevent or reduce dry mouth (xerostomia) in people getting radiation plus chemotherapy for certain head and neck cancers. It aims to see how well the approach is tolerated and whether it can protect saliva function during treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed advanced squamous cell cancer in the throat area (nasopharynx, oropharynx, larynx, or hypopharynx) scheduled for chemoradiation at Stanford
- Your cancer staging fits specific AJCC Stage II–IV ranges for each throat site (including some HPV-related and unknown-primary situations with involved lymph nodes)
- You can take d-limonene gelcaps by mouth at enrollment (you are able to swallow them)
- Your body is strong enough for treatment (ECOG performance status 0 or 1)
- Your blood, liver, and kidney tests are high enough for safe study treatment (meeting set lab cutoffs within 2 weeks)
- You have no citrus allergy history that caused an allergic reaction, and you are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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