Clin2
NCT07039370Possibly a fitRecruiting

TMS for depression: looking for brain signals of response

Major Depression Disorder

Part of Mental health clinical trials.

This trial tests if brain scans or electrical signals can predict who will get better with TMS (transcranial magnetic stimulation) for depression. It is for people whose depression did not improve after trying two or more antidepressants.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
55 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You must have a diagnosis of major depressive disorder (MDD).
  • You have tried at least two different antidepressants or anti-obsessive medications at the right doses without success.
  • You are at least 18 years old.
  • You cannot have a history of seizures, epilepsy, or abnormal brain activity on an EEG.
  • You cannot have any metal in your head or neck (like aneurysm clips or metal fragments).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06572683Enrolling by invitation
Novel TMS for hard-to-treat depression

This trial tests a new type of transcranial magnetic stimulation (TMS) for people with severe depression that hasn't improved with multiple medications or therapy. It uses a different frequency pattern to target brain circuits.

Los Angeles, California
NCT07043738Not yet recruiting
Comparing two ways to target brain stimulation for depression

This study tests two methods of targeting repetitive transcranial magnetic stimulation (TMS) for depression: one using brain imaging to guide the treatment, and the other using a standard scalp measurement. The goal is to see if imaging-guided TMS works better for people with treatment-resistant depression.

NCT07853989Not yet recruiting
Brain stimulation therapy for depression

This study tests a treatment called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate areas of the brain involved in mood. It aims to see if TMS can help people with depression by improving how they cope with stress and daily functioning.

Tekirdağ
NCT06562153Recruiting
fMRI-guided TMS for depression

This trial tests whether combining fMRI brain scans with TMS (a non-invasive brain stimulation) can help treat depression more effectively. It is for adults with major depressive disorder who can safely undergo MRI.

Charleston, South Carolina
NCT04041479Recruiting· Phase 3
Brain-scan guided rTMS for treatment-resistant depression

This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.

Stanford, California
NCT07242105Recruiting
Improving brain activity in depression

This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.

Iowa City, California

Hear when a new Major Depression Disorder trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.