TMS for depression: looking for brain signals of response
Part of Mental health clinical trials.
This trial tests if brain scans or electrical signals can predict who will get better with TMS (transcranial magnetic stimulation) for depression. It is for people whose depression did not improve after trying two or more antidepressants.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a diagnosis of major depressive disorder (MDD).
- You have tried at least two different antidepressants or anti-obsessive medications at the right doses without success.
- You are at least 18 years old.
- You cannot have a history of seizures, epilepsy, or abnormal brain activity on an EEG.
- You cannot have any metal in your head or neck (like aneurysm clips or metal fragments).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new type of transcranial magnetic stimulation (TMS) for people with severe depression that hasn't improved with multiple medications or therapy. It uses a different frequency pattern to target brain circuits.
This trial tests if using brain imaging to guide the placement of transcranial magnetic stimulation (TMS) works better than the usual scalp-based targeting method for adults with treatment-resistant depression.
This trial tests whether combining fMRI brain scans with TMS (a non-invasive brain stimulation) can help treat depression more effectively. It is for adults with major depressive disorder who can safely undergo MRI.
This trial tests whether a non-surgical brain stimulation technique (rTMS) can reduce depression symptoms in adults with major depression. You would likely have several study visits that include brain scans (MRI) and treatment sessions to see if symptoms improve.
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.
Hear when a new Major Depression Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.