Asciminib with or without sildenafil for recurrent brain tumors
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This study tests whether adding a drug called sildenafil (commonly known as Viagra) to the cancer drug asciminib can help treat brain tumors that have come back or grown after previous treatment. The goal is to see if the combination is safe and may slow tumor growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 39 years old.
- You have a brain tumor that has come back or grown, and it is in the main part of the brain.
- You are healthy enough to have surgery or a biopsy to remove or sample the tumor.
- Your blood counts (white cells, platelets, and hemoglobin) are within acceptable levels.
- Your kidney and liver function are normal or close to normal.
- You can swallow pills and are willing to have follow-up visits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a drug called sotorasib in people with brain tumors who are already scheduled for surgery or a biopsy. It may help find out if the drug can reach and treat the tumor.
This trial studies giving cetuximab (a targeted antibody) directly into an artery along with repeat radiation to treat certain recurring or treatment-resistant brain tumors. It may help by delivering the drug more directly to tumor areas and testing whether this approach can control the disease after it comes back.
This trial tests the drug asciminib for people with HER2-positive breast cancer that has spread to the brain and is growing. It may be an option if you have already tried standard treatments like T-DXd and tucatinib.
This trial tests an experimental drug, BMS-986504, for people with recurrent glioblastoma (a type of brain cancer). The drug targets a specific genetic change in the tumor. It aims to see if the drug can help shrink or slow the tumor.
This trial studies silibinin, a natural substance, to help prevent brain metastasis from coming back after surgery. It is for people with lung (NSCLC) or breast cancer who have exactly one small brain metastasis that is fully removed and has a specific lab marker in the brain tissue.
This study tests if sildenafil (a blood pressure medicine) can help prevent memory and thinking problems that some women with breast cancer may experience. It might help protect your brain during treatment.
Hear when a new Brain Tumor trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.