Treatment
Sildenafil clinical trials
We’re tracking 21 recruiting studies that include Sildenafil, each written for real people, not researchers, below.
Recruiting studies
- NCT05782244RecruitingPhase 2
Sildenafil trial for long-term brain blood-flow problems after TBI
This Phase 2 study tests whether sildenafil (a medication better known for erectile function) can improve long-term symptoms and brain blood-flow issues after a past traumatic brain injury (TBI). It may help by improving blood vessel function in the brain and possibly reducing persistent post-concussion symptoms.
Philadelphia, PennsylvaniaAges 18–70 - NCT06237751Recruiting
Sildenafil before liver surgery
This trial tests if taking sildenafil before liver surgery helps patients. It is for people having a partial liver removal who are in fairly good health.
Chenzhou, HunanAges 18–85 - NCT07391579RecruitingPhase 4
Daily Cialis Plus On-Demand Viagra for Hard-to-Treat ED
This trial tests if taking one Cialis pill daily and a Viagra pill only when needed works better for men who have tried ED pills before but they didn't help. It aims to find a new way to help men who haven't responded to standard ED treatments.
Al Mansurah, Dakahlia GovernorateAges 21 years+ - NCT07713914RecruitingPhase 4
Triple therapy vs sildenafil dose increase for PAH
This study compares two approaches for people with PAH whose current treatment (a combination of sildenafil and an endothelin receptor antagonist) needs to be stepped up. Half the participants will add a third medicine (iloprost or selexipag), while the other half will increase their sildenafil dose. The goal is to see which strategy works better for improving symptoms and lowering risk.
São Paulo, São PauloAges 18 years+ - NCT04565925RecruitingPhase 2
Sildenafil to reduce urine leaks after spinal cord injury
This trial studies whether sildenafil (a prescription pill) can lessen urinary incontinence in adults with spinal cord injuries. If it works, it may reduce the number of urine leakage episodes each week.
College Station, TexasAges 18–70 - NCT04797286RecruitingPhase 2
Sildenafil for early lung blood-pressure problems in scleroderma
This trial tests whether sildenafil can improve early “high pressure in the lung blood vessels” in people with scleroderma. It may help slow worsening breathing and lung blood-vessel disease before it becomes severe.
New Orleans, LouisianaAges 18 years+ - NCT04898114RecruitingPhase 1/Phase 2
Inhaled magnesium and sildenafil for newborn lung blood pressure
This study tests whether breathing in magnesium sulfate and giving sildenafil can improve breathing and lung blood vessel pressure in newborns with persistent pulmonary hypertension. It may help newborns who are having trouble oxygenating despite being on a ventilator.
SohagAges 6 hours–3 days - NCT05061368RecruitingPhase 2
Sildenafil by mouth to improve breathing in COPD
This Phase 2 trial tests whether sildenafil tablets can improve exercise ability, shortness of breath, and heart-lung function in people with COPD. It also compares against people without COPD to better understand how sildenafil affects breathing tests.
Edmonton, AlbertaAges 40–80 - NCT06098833RecruitingPhase 2
Sildenafil for newborn brain injury after birth asphyxia
This trial tests whether a liquid form of the medicine sildenafil can help repair brain damage in newborns who had a difficult birth and were treated with cooling. If your baby meets the cooling criteria and has brain injury on an MRI, this study may offer an additional treatment option.
Montreal, QuebecAges birth–2 days - NCT06123156RecruitingPhase 3
Early erectile rehabilitation after rectal cancer treatment
This trial tests if sildenafil (Viagra) given soon after surgery and radiation for rectal cancer can help preserve erectile function. It is for men with normal erectile function before treatment who have a regular partner.
AmiensAges 18–70 - NCT06510322RecruitingEarly Phase 1
Sildenafil for LVAD support
This trial tests whether sildenafil (the drug in Viagra) can help reduce blood vessel changes in people with a left ventricular assist device (LVAD). It aims to improve heart-pump function and overall health.
The Bronx, New YorkAges 18 years+ - NCT06872866RecruitingPhase 1
Study of sildenafil with and without food in healthy men
This study looks at how taking the study drug Hezkue Turbo (sildenafil) with food affects its levels in the body compared to taking it on an empty stomach. Healthy male volunteers aged 20 to 70 can participate.
New York, New YorkAges 20–70 - NCT06715280RecruitingPhase 4
Switching from sildenafil to riociguat for CTEPH
This trial tests switching from sildenafil to a newer medicine called riociguat for people with CTEPH (a type of lung blood pressure problem) who still have symptoms after a balloon procedure. The goal is to see if the switch helps them feel better.
Hong KongAges 18 years+ - NCT06324396RecruitingPhase 1
Improving drug dosing for single ventricle patients with liver disease
This trial studies how the drugs sildenafil and pravastatin work in people with a single ventricle heart condition who have had the Fontan surgery and may have related liver problems. The goal is to find the best doses based on liver function.
Kansas City, MissouriAges 8 years+ - NCT07377084Recruiting
Study of chemicals in head and neck cancer samples
This study looks at the chemical signatures (metabolomics) in blood and tumor tissue from people with head and neck cancer. It aims to find markers that may help predict treatment response or tailor future care.
NiceAges 18 years+ - NCT06875258RecruitingPhase 4
Penile rehab after nerve-sparing prostate surgery
This trial tests a penile rehabilitation program for men who have nerve-sparing prostate cancer surgery. It aims to help improve erections and sexual function after the procedure.
Nijmegen, GelderlandAges 18–70 - NCT05201144RecruitingPhase 2
Test of sildenafil after diaphragm hernia surgery in newborns
This trial studies whether sildenafil (a medicine that helps relax blood vessels) can improve outcomes in babies born with a congenital diaphragmatic hernia (CDH) after they’ve had surgery. Babies are selected based on an ultrasound/echo of heart function after repair.
Salt Lake City, UtahAges Any age - NCT06649539RecruitingPhase 4
Delayed-dose collagenase injections for Peyronie's disease
This trial tests a delayed-dose schedule of collagenase (an enzyme that breaks down hard scar tissue) injections for men with Peyronie's disease (curved, painful erections). It may help straighten the penis and improve sexual function.
Orem, UtahAges 18 years+ - NCT06954597RecruitingPhase 2
Testing a new cream for scleroderma finger ulcers
This study tests a new cream (TOP-N53) for digital ulcers caused by scleroderma. The cream is applied directly to the sore, and the goal is to see if it is safe and helps the ulcer heal.
BordeauxAges 18 years+ - NCT07135037RecruitingPhase 2
Comparing treatments for low amniotic fluid in pregnancy
This trial tests different treatments for low amniotic fluid (oligohydramnios) in pregnant women. It aims to find which treatment works best for women who are also scheduled for a planned C-section.
Kafr ash Shaykh, KafrelsheikhAges 18–35 - NCT07462260RecruitingPhase 2/Phase 3
Sildenafil for severe pulmonary hypertension from rheumatic valve disease
This trial tests if sildenafil can help people with severe pulmonary hypertension caused by rheumatic valvular heart disease. It aims to see if the drug improves symptoms and heart function.
Hyderābād, SindhAges 18 years+
What Sildenafil is being studied for
Conditions with recruiting Sildenafil studies.
Common questions
- Are there clinical trials studying Sildenafil?
- Yes. Clin2 currently lists 21 recruiting studies that include Sildenafil, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Sildenafil trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Sildenafil an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Sildenafil or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.